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L14298 (S)-(+)-Epichlorohydrin, 98+%

CAS Number
67843-74-7
Synonyms
(S)-(+)-1-Chloro-2,3-epoxypropane

Stock No. Size Price ($) Quantity Availability
L14298-03 1g 45.00
L14298-06 5g 116.00
L14298-14 25g 324.00
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(S)-(+)-Epichlorohydrin, 98+%

MDL
MFCD00077760

Chemical Properties

Formula
C3H5ClO
Formula Weight
92.53
Boiling Point
116-117°
Flash Point
32°(90°F)
Density
1.180
Refractive Index
1.4380
Storage & Sensitivity
Keep Cold.
Solubility
Miscible with chloroform and methanol. Immiscible with water.

Applications

(S)-(+)-Epichlorohydrin is utilized for the synthesis of macquarimicins and hydroxyisoxazolidines and (+)-cis-sylvaticin, which is a potential antitumor agent. It is used to synthesize inhibitors of fatty acid oxidation as potential metabolic modulators. It acts as a solvent for natural and synthetic resins, gums, cellulose esters and ethers, paints, varnishes, nail enamels, lacquers and cement for celluloid. It is also used as a stabilizer and also useful as a bifunctional alkylating agent with the potential to form DNA cross-links.

Notes

Hygroscopic. Store in a cool place. Incompatible with acids, bases, ammonia, amines, sodium and sodium oxides, zinc, magnesium, aluminum and its alloys and halides.

Literature References

Xue, F.; Liu, Z. Q.; Wang, Y. J.; Zhu, H. Q.; Wan, N. W.; Zheng, Y. G. Efficient synthesis of (S)-epichlorohydrin in high yield by cascade biocatalysis with halohydrin dehalogenase and epoxide hydrolase mutants. Catal. Commun. 2015, 72, 147-149.

Gajare, V. S.; Khobare, S. R.; Malavika, B.; Rajana, N.; Rao, B. V.; Kumar, U. K. S. A short diastereoselective synthesis of cis-(2S,4S) and cis-(2R,4R)-4-hydroxyprolines. Tetrahedron Lett. 2015, 56 (24), 3743-3746.

GHS Hazard and Precautionary Statements

Hazard Statements: H226-H301+H311+H331-H314-H317-H350

Flammable liquid and vapour. Toxic if swallowed. Toxic in contact with skin. Toxic if inhaled. Causes severe skin burns and eye damage. May cause an allergic skin reaction. May cause cancer.

Precautionary Statements: P201-P202-P210-P233-P235-P240-P241-P242-P243-P260-P264b-P270-P271-P272-P280g-P281-P303+P361+P353-P304+P340-P305+P351+P338-P310-P330-P331-P333+P313-P363-P370+P378q-P501c

Obtain special instructions before use. Do not handle until all safety precautions have been read and understood. Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Keep container tightly closed. Keep cool. Ground/bond container and receiving equipment. Use explosion-proof electrical/ventilating/lighting/ equipment. Use only non-sparking tools. Take precautionary measures against static discharge. Do not breathe dust/fume/gas/mist/vapours/spray. Wash face, hands and any exposed skin thoroughly after handling Do not eat, drink or smoke when using this product. Use only outdoors or in a well-ventilated area. Contaminated work clothing should not be allowed out of the workplace. Wear protective gloves. Use personal protective equipment as required. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Immediately call a POISON CENTER or doctor/physician. Rinse mouth. Do NOT induce vomiting. If skin irritation or rash occurs: Get medical advice/attention. Wash contaminated clothing before reuse. In case of fire: Use CO2, dry chemical, or foam Dispose of contents/ container to an approved waste disposal plant

Other References

Beilstein
1420784
Hazard Class
6.1
Packing Group
II
Harmonized Tariff Code
2910.30
TSCA
No
RTECS
RR0427100

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