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67843-74-7 - (S)-(+)-Epichlorohydrin, 98+% - (S)-(+)-1-Chloro-2,3-epoxypropane - L14298 - Alfa Aesar

L14298 (S)-(+)-Epichlorohydrin, 98+%

CAS Number
67843-74-7
Synonyms
(S)-(+)-1-Chloro-2,3-epoxypropane

Size Price ($) Quantity Availability
1g 47.28
5g 108.90
25g 324.90
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(S)-(+)-Epichlorohydrin, 98+%

MDL
MFCD00077760

Chemical Properties

Formula
C3H5ClO
Formula Weight
92.53
Boiling Point
116-117°
Flash Point
32°(90°F)
Density
1.180
Refractive Index
1.4380
Solubility
Miscible with chloroform and methanol. Immiscible with water.

Applications

(S)-(+)-Epichlorohydrin is utilized for the synthesis of macquarimicins and hydroxyisoxazolidines and (+)-cis-sylvaticin, which is a potential antitumor agent. It is used to synthesize inhibitors of fatty acid oxidation as potential metabolic modulators. It acts as a solvent for natural and synthetic resins, gums, cellulose esters and ethers, paints, varnishes, nail enamels, lacquers and cement for celluloid. It is also used as a stabilizer and also useful as a bifunctional alkylating agent with the potential to form DNA cross-links.

Notes

Hygroscopic. Store in a cool place. Incompatible with acids, bases, ammonia, amines, sodium and sodium oxides, zinc, magnesium, aluminum and its alloys and halides.

Literature References

Xue, F.; Liu, Z. Q.; Wang, Y. J.; Zhu, H. Q.; Wan, N. W.; Zheng, Y. G. Efficient synthesis of (S)-epichlorohydrin in high yield by cascade biocatalysis with halohydrin dehalogenase and epoxide hydrolase mutants. Catal. Commun. 2015, 72, 147-149.

Gajare, V. S.; Khobare, S. R.; Malavika, B.; Rajana, N.; Rao, B. V.; Kumar, U. K. S. A short diastereoselective synthesis of cis-(2S,4S) and cis-(2R,4R)-4-hydroxyprolines. Tetrahedron Lett. 2015, 56 (24), 3743-3746.

GHS Hazard and Precautionary Statements

Hazard Statements: H300-H310-H330-H317-H350-H314-H318-H226

Fatal if swallowed. Fatal in contact with skin. Fatal if inhaled. May cause an allergic skin reaction. May cause cancer. Causes severe skin burns and eye damage. Causes serious eye damage. Flammable liquid and vapour.

Precautionary Statements: P210-P301+P310-P303+P361+P353-P304+P340-P305+P351+P338-P320-P330-P361-P405-P501a

Keep away from heat/sparks/open flames/hot surfaces. - No smoking. IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Specific treatment is urgent (see label). Rinse mouth. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Beilstein
1420784
Hazard Class
6.1
Packing Group
II
Harmonized Tariff Code
2910.30
TSCA
No
RTECS
RR0427100

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