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19810-31-2 - Benzyloxyacetyl chloride, 95% - L14337 - Alfa Aesar

L14337 Benzyloxyacetyl chloride, 95%

CAS Number
19810-31-2
Synonyms

Size Price ($) Quantity Availability
1g 21.40
5g 63.60
25g 208.00
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Benzyloxyacetyl chloride, 95%

MDL
MFCD00010768

Chemical Properties

Formula
C9H9ClO2
Formula Weight
184.62
Boiling Point
84-87°/0.4mm
Flash Point
>110°(230°F)
Density
1.189
Refractive Index
1.5230
Sensitivity
Moisture Sensitive
Solubility
Reacts with water.

Applications

Benzyloxyacetyl chloride is a reagent used to construct substituted 2-azetidinones for further elaboration into annulated β-lactams. It is a commonly employed reagent for asymmetric synthesis of β-lactams. It is also used in preparation of (S)-3-(methylamino)-3-((R)-pyrrolidin-3-yl)propanenitrile, key intermediate in the preparation of fluoroquinolone antibiotic for respiratory tract infections, non-racemic helicene and β-lactams.

Notes

It is sensitive to moisture. Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage. Recommended storage temperature is 2 - 8°C. Store under inert gas.

Literature References

Gerard, B.; Cencic, R.; Pelletier, J.; Porco, John A. Enantioselective Synthesis of the Complex Rocaglate (-)-Silvestrol. Angew. Chem. Int. Ed. 2007, 46 (41), 7831-7834.

Colin Nuckolls.; Thomas J. Katz. Synthesis, Structure, and Properties of a Helical Columnar Liquid Crystal. J. Am. Chem. Soc. 1998, 120 (37), 9541-9544.

GHS Hazard and Precautionary Statements

Hazard Statements: H314-H318

Causes severe skin burns and eye damage. Causes serious eye damage.

Precautionary Statements: P260u-P303+P361+P353-P305+P351+P338-P301+P330+P331-P405-P501a

Do not breathe dusts or mists. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Beilstein
1947363
Hazard Class
8
Packing Group
II
Harmonized Tariff Code
2918.99
TSCA
No

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