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63148-57-2 - Poly(methylhydrosiloxane) - Methyl hydrogen polysiloxane - PMHS - L14561 - Alfa Aesar

L14561 Poly(methylhydrosiloxane)

CAS Number
Methyl hydrogen polysiloxane

Size Price ($) Quantity Availability
50g 24.50
250g 43.40
1000g 142.00
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Chemical Properties

Formula Weight
ca 1900
Flash Point
Refractive Index
Not miscible or difficult to mix in water.


Poly(methylhydrosiloxane) is used in the reduction of esters to alcohols, catalyzed by a combination of titanocene dichloride and either n-BuLi or EtMgBr. It is a safer alternative to triethoxysilane, B22063, for reduction of phosphine oxides to phosphines, catalyzed by Ti(O-i-Pr)4. It is also used in greener amine synthesis by reductive amination as an alternative to borohydrides.


Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage. Incompatible with strong oxidizing agents, amines and bases.

Literature References

Bhanu P. S. Chauhan.; Rajesh Sardar. Self-Assembled Stable Silver Nanoclusters and Nanonecklace Formation:? Poly(methylhydrosiloxane)-Mediated One-Pot Route to Organosols. Macromolecules. 2004, 37 (14), 5136-5139.

Bhanu P.S. Chauhan.; Philip Boudjouk. New neutral carrier-type ion sensors. Crown ether derivatives of poly(methylhydrosiloxane). Tetrahedron Letters. 1999, 40 (22), 4123-4126.

Convenient reducing agent with a wide variety of applications, for example:

Reduction of esters to alcohols, catalyzed by a combination of titanocene dichloride and either n-BuLi or EtMgBr: J. Org. Chem., 59, 4323 (1994). Alternatively, in combination with Ti(O-i-Pr)4 reduces a variety of esters, generally in high yield: J. Org. Chem., 60, 7884 (1995); Synlett, 831 (1994). For one-step reductive amination of carbonyl compounds in similar fashion, see: Synlett, 1655 (2000). Reduction of esters, carboxylic acids, ketones and aldehydes can also be accomplished conveniently with TBAF as a catalyst: Synlett, 989 (1997). For asymmetric reduction of ketones catalyzed by chiral quaternary fluorides, see: Tetrahedron Lett., 38, 5857 (1997).

Low-cost, safer alternative to Triethoxysilane, B22063, for reduction of phosphine oxides to phosphines, catalyzed by Ti(O-i-Pr)4. The products may be reacted in situ with alkyl halides to give a convenient one-pot conversion of phosphine oxides to phosphonium salts: Tetrahedron Lett., 35, 625 (1994).

Amine N-oxides can be reduced in the presence of Ti(O-i-Pr)4 or Pd(0): Synlett, 349 (2002).

Pd(0)-catalyzed hydrogenolysis of alkyl and aryl halides: J. Org. Chem., 51, 734 (1986). Pd(0)-catalyzed reductive cyclization of 1,6- and 1,7-enynes to give exomethylene cyclopentanes and cyclohexanes: J. Am. Chem. Soc., 109, 3161 (1987).

Low-cost alternative to Triethyl­silane, A10320, in a one-pot aromatic acylation-reduction technique allowing alkylation of the aromatic ring without the polysubstitution and rearrangements associated with Friedel-Crafts alkylations. Acylation in the presence of AlCl3 is followed by in situ reduction with PMHS: J. Chem. Soc., Perkin 1, 1705 (1989).

For a review of PMHS, see: J. Chem. Soc., Perkin 1, 3381 (1999).

GHS Hazard and Precautionary Statements

Precautionary Statements: P260u-P201-P280-P303+P361+P353-P305+P351+P338-P301+P330+P331-P304+P340-P310a-P405-P501a

Obtain special instructions before use. Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

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