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520-36-5 - 4',5,7-Trihydroxyflavone, 97% - Apigenin - L15041 - Alfa Aesar

L15041 4',5,7-Trihydroxyflavone, 97%

CAS Number
520-36-5
Synonyms
Apigenin

Size Price ($) Quantity Availability
25mg 44.91
100mg 121.54
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4',5,7-Trihydroxyflavone, 97%

MDL
MFCD00006831
EINECS
208-292-3

Chemical Properties

Formula
C15H10O5
Formula Weight
270.24
Melting point
ca 315° dec.
Solubility
Soluble in dimethyl sulfoxide (27 mg/ml) or 1M potassium hydroxide (50mg/ml).

Applications

4',5,7-Trihydroxyflavone is a nonmutagenic flavonoid shown to inhibit cell proliferation, angiogenesis and protein kinase. Also induces apoptosis in breast cancer cells. It inhibit topoisomerase I-catalyzed DNA re-ligation and enhance gap junctional intercellular communication.

Notes

Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Incompatible with and strong oxidizing agents.

Literature References

Hirano T.; Oka K.; Akiba M. Antiproliferative effects of synthetic and naturally occurring flavonoids on tumor cells of the human breast carcinoma cell line, ZR-75-1. Research Communications in Chemical Pathology and Pharmacology. 1989, 64 (1), 69-78.

Sunanda Panda.; Anand Kar. Apigenin (4‘,5,7-trihydroxyflavone) regulates hyperglycaemia, thyroid dysfunction and lipid peroxidation in alloxan-induced diabetic mice. Journal of Pharmacy and Pharmacology. 2007, 59 (11), 1543-1548.

GHS Hazard and Precautionary Statements

Hazard Statements: H315-H319-H335

Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Precautionary Statements: P261-P280-P305+P351+P338-P304+P340-P362-P312-P321-P405-P403+P233-P501a

Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Take off contaminated clothing and wash before reuse. Call a POISON CENTER or doctor/physician if you feel unwell. Specific treatment (see label). Store locked up. Store in a well-ventilated place. Keep container tightly closed. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Merck
14,730
Beilstein
262620
Harmonized Tariff Code
2932.99
TSCA
No
RTECS
LK9276000

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