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L15041 4',5,7-Trihydroxyflavone, 97%

CAS Number
520-36-5
Synonyms
Apigenin

Stock No. Size Price ($) Quantity Availability
L15041-MB 25mg 45.90
L15041-MC 100mg 123.00
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4',5,7-Trihydroxyflavone, 97%

MDL
MFCD00006831
EINECS
208-292-3

Chemical Properties

Formula
C15H10O5
Formula Weight
270.24
Melting point
ca 315° dec.
Storage & Sensitivity
Keep Cold.
Solubility
Soluble in dimethyl sulfoxide (27 mg/ml) or 1M potassium hydroxide (50mg/ml).

Applications

4',5,7-Trihydroxyflavone is a nonmutagenic flavonoid shown to inhibit cell proliferation, angiogenesis and protein kinase. Also induces apoptosis in breast cancer cells. It inhibit topoisomerase I-catalyzed DNA re-ligation and enhance gap junctional intercellular communication.

Notes

Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Incompatible with and strong oxidizing agents.

Literature References

Hirano T.; Oka K.; Akiba M. Antiproliferative effects of synthetic and naturally occurring flavonoids on tumor cells of the human breast carcinoma cell line, ZR-75-1. Research Communications in Chemical Pathology and Pharmacology. 1989, 64 (1), 69-78.

Sunanda Panda.; Anand Kar. Apigenin (4‘,5,7-trihydroxyflavone) regulates hyperglycaemia, thyroid dysfunction and lipid peroxidation in alloxan-induced diabetic mice. Journal of Pharmacy and Pharmacology. 2007, 59 (11), 1543-1548.

GHS Hazard and Precautionary Statements

Hazard Statements: H315-H319-H335

Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Precautionary Statements: P261-P264b-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P337+P313-P362-P501c

Avoid breathing dust/fume/gas/mist/vapours/spray. Wash face, hands and any exposed skin thoroughly after handling Use only outdoors or in a well-ventilated area. Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN: Wash with plenty of soap and water. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Call a POISON CENTER or doctor/physician if you feel unwell. If skin irritation occurs: Get medical advice/attention. If eye irritation persists: Take off contaminated clothing and wash before reuse. Dispose of contents/ container to an approved waste disposal plant

Other References

Merck
14,730
Beilstein
262620
Harmonized Tariff Code
2932.99
TSCA
No
RTECS
LK9276000

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