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39394-84-8 - Eaton's Reagent, P<sub>2</sub>O<sub>5</sub> ca 7.5% w/w - Phosphorus pentoxide, 7.5 wt % in methanesulfonic acid - L15607 - Alfa Aesar

L15607 Eaton's Reagent, P2O5 ca 7.5% w/w

CAS Number
39394-84-8
Synonyms
Phosphorus pentoxide, 7.5 wt % in methanesulfonic acid

Size Price ($) Quantity Availability
100ml 37.90
500ml 134.93
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Eaton's Reagent, P2O5 ca 7.5% w/w

MDL
MFCD00070545

Chemical Properties

Formula
O5P2
Formula Weight
141.95
Flash Point
>110°(230°F)
Density
1.515
Refractive Index
1.4350
Sensitivity
Moisture Sensitive
Solubility
Decomposes in water.

Applications

Eaton's Reagent is used in the synthesis fluorine-based hole-transporting material, mono and bis-chalcone derivatives via Claisen-Schmidt condensation reaction between arylaldehydes and ketones and 4-hydroxycoumarins and 4-hydroxy-2-quinolinones derivatives.

Notes

Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage.

Literature References

Luckner G. Ulysse.; Qiang Yang.; Mark D. McLaws.; Daniel K. Keefe.; Peter R. Guzzo.; Brian P. Haney. Process Development and Pilot-Scale Synthesis of New Cyclization Conditions of Substituted Phenylacetamides to Tetrahydroisoquinoline-2-ones Using Eaton’s Reagent. Org. Process Res. Dev. 2010, 14 (1), 225-228.

Rex X Ren.; Larisa D Zueva.; Wei Ou. Formation of ε-caprolactam via catalytic Beckmann rearrangement using P2O5 in ionic liquids. Tetrahedron Letters. 2001, 42 (48), 8441-8443.

Lower viscosity alternative to polyphosphoric acid for dehydration and cyclization reactions. Gives high yields in the Beckmann rearrangement: J. Org. Chem., 35, 4071 (1973). For an example of cyclodehydration, see: J. Chem. Soc., Perkin 1, 2956 (1981).

For further examples and discussion of the utility of this reagent, see: Encyclopedia of Reagents for Organic Synthesis, L. A. Paquette, Ed., Wiley, Chichester (1995), vol. 6, p. 4129.

GHS Hazard and Precautionary Statements

Hazard Statements: H314-H318-H302

Causes severe skin burns and eye damage. Causes serious eye damage. Harmful if swallowed.

Precautionary Statements: P280-P305+P351+P338-P309-P310

Wear protective gloves/protective clothing/eye protection/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF exposed or if you feel unwell: Immediately call a POISON CENTER or doctor/physician.

Other References

Hazard Class
8
Packing Group
II
Harmonized Tariff Code
2904.10
TSCA
No

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