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L15661 2-Bromo-5-nitropyridine, 98+%

CAS Number
4487-59-6
Synonyms

Stock No. Size Price ($) Quantity Availability
L15661-03 1g 24.10
L15661-06 5g 74.60
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2-Bromo-5-nitropyridine, 98+%

MDL
MFCD00006222
EINECS
224-777-2

Chemical Properties

Formula
C5H3BrN2O2
Formula Weight
203.00
Melting point
136-140°
Boiling Point
145-147°/10mm
Storage & Sensitivity
Ambient temperatures.
Solubility
Insoluble in water.

Applications

2-Bromo-5-nitropyridine was used in preparation of boc-protected (piperazin-1-ylmethyl)biaryls via microwave-mediated Suzuki-Miyaura coupling with (boc-piperazin-1-ylmethyl)phenylboronic acid pinacol esters. It was also used in the synthesis of 2-pyridyl analogs. Substituted 5-nitro-2-ethynylpyridines were synthesized by the Sonogashira reaction of 2-bromo-5-5-nitropyridine with terminal acetylenes.

Notes

Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Store away from strong oxidizing agents.

Literature References

Spencer J, et al. Synthesis of a (piperazin-1-ylmethyl) biaryl library via microwave-mediated Suzuki-Miyaura cross-couplings.. Tetrahedron Lett. 201152 (31), 3963-68.

Hashim Motiwala et. al. Exploration of pyridine containing heteroaryl analogs of biaryl ureas as DGAT1 inhibitors. Bioorganic & Medicinal Chemistry Letters, . 2011, 21 (19), 5812-5817.

GHS Hazard and Precautionary Statements

Hazard Statements: H302-H312-H315-H319-H335

Harmful if swallowed. Harmful in contact with skin. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Precautionary Statements: P280h-P305+P351+P338

Wear protective gloves/clothing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

Other References

Beilstein
120901
Harmonized Tariff Code
2933.39
TSCA
No

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