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623-49-4 - Ethyl cyanoformate, 99% - Cyanoformic acid ethyl ester - L15777 - Alfa Aesar

L15777 Ethyl cyanoformate, 99%

CAS Number
623-49-4
Synonyms
Cyanoformic acid ethyl ester

Size Price ($) Quantity Availability
5g 30.40
25g 93.50
100g 307.00
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Ethyl cyanoformate, 99%

MDL
MFCD00001836
EINECS
210-797-9

Chemical Properties

Formula
NCCO2CH2CH3
Formula Weight
99.09
Boiling Point
115-116°
Flash Point
24°(75°F)
Density
1.003
Refractive Index
1.3820
Sensitivity
Moisture Sensitive
Solubility
Miscible with chloroform and methanol.

Applications

Ethyl cyanoformate is used as reagent in the preparation of N-substituted amindinoformic acid and ethyl-4-quinazoline -2-carboxylate.

Notes

Moisture sensitive. Keep the container tightly closed in a dry and well-ventilated place. Incompatible with strong acids, strong bases, strong oxidizing agents and strong reducing agents.

Literature References

Reagent for ethoxycarbonylation of enolate anions: Tetrahedron, 43, 45 (1987). In the presence of ZnCl2, active methylene compounds are converted to ɑ-amino acrylate esters: Tetrahedron. Lett, 2525 (1979).

North, M.; Urwin, S. Kinetics and mechanism of base catalysed ethyl cyanoformate addition to aldehydes. Tetrahedron 2014, 70 (40), 7100-7105.

Ji, N., Yao, L.; He, W.; Li, Y. Bifunctional Schiff base/Ti (IV) catalysts for enantioselective cyanoformylation of aldehydes with ethyl cyanoformate. Appl. Organomet. Chem. 2013, 27 (4), 209-213.

GHS Hazard and Precautionary Statements

Hazard Statements: H300-H310-H330-H314-H318-H226

Fatal if swallowed. Fatal in contact with skin. Fatal if inhaled. Causes severe skin burns and eye damage. Causes serious eye damage. Flammable liquid and vapour.

Precautionary Statements: P210-P301+P310-P303+P361+P353-P304+P340-P305+P351+P338-P320-P330-P361-P405-P501a

Keep away from heat/sparks/open flames/hot surfaces. - No smoking. IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Specific treatment is urgent (see label). Rinse mouth. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Beilstein
635955
Hazard Class
6.1
Packing Group
II
Harmonized Tariff Code
2926.90
TSCA
Yes

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