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565-53-7 - Ethyl dibromofluoroacetate, 97% - Dibromofluoroacetic acid ethyl ester - L16491 - Alfa Aesar

L16491 Ethyl dibromofluoroacetate, 97%

CAS Number
565-53-7
Synonyms
Dibromofluoroacetic acid ethyl ester

Size Price ($) Quantity Availability
5g 77.60
25g 267.00
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Ethyl dibromofluoroacetate, 97%

MDL
MFCD00042068

Chemical Properties

Formula
Br2C4FH5O2
Formula Weight
263.89
Boiling Point
82°/33mm
Flash Point
>110°(230°F)
Density
1.894
Refractive Index
1.4635
Solubility
Miscible with most organic solvents. Immiscible with water.

Applications

Ethyl dibromofluoroacetate is a reagent used in the preparation of fluorinated molecules in organic synthesis. It is involved in the Reformatsky-type reaction to prepare syn-alfa-bromo-alfa-fluoro-beta-lactams by using diethylzinc. It is also used to prepare 2-fluoroaziridine-2-carboxylates by reaction with imines.

Notes

Incompatible with oxidizing agents and bases.

Literature References

Tarui, A.; Tanaka, A.; Ueo, M.; Sato, K.; Omote, M.; Ando, A. Synthesis of a fluorinated Ezetimibe analogue using radical allylation of alpha-bromo-alpha-fluoro-beta-lactam. New J. Chem. 2015, 39 (12), 9325-9329.

Tarui, A.; Nishimura, H.; Ikebata, T.; Tahira, A.; Sato, K.; Omote, M.; Minami, H.; Miwa, Y.; Ando, A. Ligand-Promoted Asymmetric Imino-Reformatsky Reaction of Ethyl Dibromofluoroacetate. Org. Lett. 2014, 16 (8), 2080-2083.

GHS Hazard and Precautionary Statements

Hazard Statements: H314-H318-H302-H312

Causes severe skin burns and eye damage. Causes serious eye damage. Harmful if swallowed. Harmful in contact with skin.

Precautionary Statements: P260-P280-P303+P361+P353-P305+P351+P338-P301+P330+P331-P304+P340-P310-P301+P312-P405-P501a

Do not breathe dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Immediately call a POISON CENTER or doctor/physician. Call a POISON CENTER or doctor/physician if you feel unwell. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Beilstein
1762048
Hazard Class
8
Packing Group
III
Harmonized Tariff Code
2915.39
TSCA
No

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