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65094-22-6 - Diethyl (bromodifluoromethyl)phosphonate, 97% - Bromodifluoromethyl diethyl phosphonate - Diethyl bromodifluoromethanephosphonate - L16715 - Alfa Aesar

L16715 Diethyl (bromodifluoromethyl)phosphonate, 97%

CAS Number
65094-22-6
Synonyms
Bromodifluoromethyl diethyl phosphonate
Diethyl bromodifluoromethanephosphonate

Size Price ($) Quantity Availability
1g 18.40
5g 66.54
25g 231.42
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Diethyl (bromodifluoromethyl)phosphonate, 97%

MDL
MFCD00069118

Chemical Properties

Formula
C5H10BrF2O3P
Formula Weight
267.01
Boiling Point
99-102°/16mm
Flash Point
>110°(230°F)
Density
1.503
Refractive Index
1.4160
Solubility
Not miscible or difficult to mix in water.

Applications

Diethyl (bromodifluoromethyl)phosphonate is used as a reactant for the preparation of phosphopeptide mimetic prodrugs targeted to Src homology 2 (SH2) domain of signal transducer and activator of transcription 3 (Stat3), synthesis of Mycobacterium tuberculosis protein tyrosine phosphatase inhibitory difluoromethylphosphonic acid derivatives via multi step synthesis with Suzuki coupling and resolution as key steps and P-C bond cleavage on basic hydrolysis.

Notes

Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage. Incompatible with oxidizing agents.

Literature References

Pijus K Mandal.; Fengqin Gao.; Zhen Lu.; Zhiyong Ren.; Rajagopal Ramesh.; J Sanderson Birtwistle.; Kumaralal K Kaluarachchi.; Xiaomin Chen.; Robert C Bast.; Warren S Liao.; John S McMurray. Potent and selective phosphopeptide mimetic prodrugs targeted to the Src homology 2 (SH2) domain of signal transducer and activator of transcription 3. Journal of medicinal and pharmaceutical chemistry. 2011, 54 (10), 3549-3563.

Katherine A Rawls.; Christoph Grundner.; Jonathan A Ellman. Design and synthesis of nonpeptidic, small molecule inhibitors for the Mycobacterium tuberculosis protein tyrosine phosphatase PtpB. Organic & Biomolecular Chemistry. 2010, 8 (18), 4066-4070.

GHS Hazard and Precautionary Statements

Hazard Statements: H315-H319

Causes skin irritation. Causes serious eye irritation.

Precautionary Statements: P280-P264-P305+P351+P338-P362-P321-P332+P313-P337+P313-P302+P352

Wear protective gloves/protective clothing/eye protection/face protection. Wash thoroughly after handling. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Take off contaminated clothing and wash before reuse. Specific treatment (see label). If skin irritation occurs: Get medical advice/attention. If eye irritation persists: IF ON SKIN: Wash with plenty of soap and water.

Other References

Beilstein
1944045
Harmonized Tariff Code
2931.90
TSCA
No

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