I agree Our site saves small pieces of text information (cookies) on your device in order to deliver better content and for statistical purposes. You can disable the usage of cookies by changing the settings of your browser. By browsing our website without changing the browser settings you grant us permission to store that information on your device.
1,3,5-Triazine is a useful replacement for HCN in the Gattermann reaction for the synthesis of aromatic aldehydes. It reacts with nucleophiles, e.g. amines, which is utilized in quinazoline synthesis.
N. G. McCormick.; J. H. Cornell.; A. M. Kaplan. Biodegradation of Hexahydro-1,3,5-Trinitro-1,3,5-Triazine. Appl. Environ. Microbiol.. 1981, 42 (5), 817-823.
Francis H. Case.; Emil Koft. The Synthesis of Certain Substituted 1,3,5-Triazines Containing the Ferroin Group. J. Am. Chem. Soc. 1959, 81 (4), 905-906.
Formylating agent: useful replacement for HCN in the Gattermann reaction for the synthesis of aromatic aldehydes: J. Am. Chem. Soc., 76, 290 (1954); Angew. Chem. Int. Ed., 6, 940 (1969); Arch. Pharm., 302, 828 (1969); 304, 362 (1971); with reactive substrates, formylation can be accomplished without a catalyst.
Also reacts with nucleophiles, e.g. amines, which has been utilized in a quinazoline synthesis: J. Chem. Soc. (C), 1282 (1969):
Hazard Statements: H302-H315-H318-H335
Harmful if swallowed. Causes skin irritation. Causes serious eye damage. May cause respiratory irritation.
Precautionary Statements: P264b-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P310-P312-P330-P332+P313-P362-P501c
Wash face, hands and any exposed skin thoroughly after handling Do not eat, drink or smoke when using this product. Use only outdoors or in a well-ventilated area. Wear protective gloves/protective clothing/eye protection/face protection. IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. IF ON SKIN: Wash with plenty of soap and water. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Immediately call a POISON CENTER or doctor/physician. Rinse mouth. If skin irritation occurs: Get medical advice/attention. Take off contaminated clothing and wash before reuse. Dispose of contents/ container to an approved waste disposal plant