Cookies disclaimer

I agree Our site saves small pieces of text information (cookies) on your device in order to deliver better content and for statistical purposes. You can disable the usage of cookies by changing the settings of your browser. By browsing our website without changing the browser settings you grant us permission to store that information on your device.

384-67-8 - 2-Chloro-2,2-difluoroacetophenone, 96% - alpha,alpha-Difluorophenacyl chloride - alpha-Chloro-alpha,alpha-difluoroacetophenone - L16963 - Alfa Aesar

L16963 2-Chloro-2,2-difluoroacetophenone, 96%

CAS Number
384-67-8
Synonyms
alpha,alpha-Difluorophenacyl chloride
alpha-Chloro-alpha,alpha-difluoroacetophenone

Size Price ($) Quantity Availability
1g 30.40
5g 71.40
Add to Cart Add to Quote Request View Item

2-Chloro-2,2-difluoroacetophenone, 96%

MDL
MFCD00042123
EINECS
000-000-0

Chemical Properties

Formula
C8H5ClF2O
Formula Weight
190.58
Boiling Point
95-97°/37mm
Flash Point
72°(161°F)
Density
1.293
Refractive Index
1.4970
Solubility
Difficult to mix.

Applications

Reagent is an effective product for the synthesis of difluoromethylated phenols in the presence of mild base and aqueous solvent.

Notes

Store away from strong oxidizing agents. Keep container tightly closed. Store in cool, dry conditions in well sealed containers.

Literature References

Laijun Zhang.; Ji Zheng.; Jinbo Hu. 2-Chloro-2,2-difluoroacetophenone:? A Non-ODS-Based Difluorocarbene Precursor and Its Use in the Difluoromethylation of Phenol Derivatives. J. Org. Chem. 2006, 71, (26), 9845-9848.

Wei Zhang.; Fei Wang.; Jinbo Hu. N-Tosyl-S-difluoromethyl-S-phenylsulfoximine: A New Difluoromethylation Reagent for S-, N-, and C-Nucleophiles. Org. Lett. 2009, 11, (10), 2109-2112.

GHS Hazard and Precautionary Statements

Hazard Statements: H315-H319-H335-H227

Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation. Combustible liquid.

Precautionary Statements: P210-P261-P280-P305+P351+P338-P304+P340-P362-P312-P405-P403+P233-P501a

Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Take off contaminated clothing and wash before reuse. Call a POISON CENTER or doctor/physician if you feel unwell. Store locked up. Store in a well-ventilated place. Keep container tightly closed. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Beilstein
2251448
Harmonized Tariff Code
2914.70
TSCA
No

Recommended

Recently Viewed

Chemicals

Life Science

Metals & Materials

Catalysts

Analytical & Labware