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It is a reactant for preparation of tryptophan dioxygenase inhibitors pyridyl-ethenyl-indoles as potential anticancer immunomodulators, reactant for preparation of indole linked triazole derivatives as antifungal agents, reactant for preparation of N-β-D-xylosyl-indole derivatives as SGLT2 inhibitors for management of hyperglycemia in diabetes, reactant for preparation of aminoguanidine derivatives of arylsulfonylacylindoles as antifungal agents, reactant for preparation of indolylindazoles and indolylpyrazolopyridines as interleukin-2 inducible T cell kinase inhibitors, reactant for preparation of arylsulfonylacetylindoles as anti-HIV-1 agents. 6-Methylindole was used in the synthesis of benz[c,d]indol-3(1H)-one derivatives.
H. R. Snyder.; Frederick J. Pilgrim. A Synthesis of 6-Methylindole and dl-6-Methyltryptophan.J. Am. Chem. Soc. 1948, 70 (11),3787-3788 .
Urs Hengartner.; Donald ValentineJr.; Katharine K. Johnson.; Mary Ellen Larscheid.; Foster Pigott.; Franz Scheidl.; John W. Scott.; Ruen C. Sun.; John M. Townsend.Synthesis of (R)-6-methyltryptophan via enantioselective catalytic hydrogenation. J. Org. Chem. 1979, 44 (22),3741-3747 .
Hazard Statements: H315-H319-H335
Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.
Precautionary Statements: P261-P264b-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P337+P313-P362-P501c
Avoid breathing dust/fume/gas/mist/vapours/spray. Wash face, hands and any exposed skin thoroughly after handling Use only outdoors or in a well-ventilated area. Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN: Wash with plenty of soap and water. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Call a POISON CENTER or doctor/physician if you feel unwell. If skin irritation occurs: Get medical advice/attention. If eye irritation persists: Take off contaminated clothing and wash before reuse. Dispose of contents/ container to an approved waste disposal plant