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2-Amino-5-Chlorobenzaldehyde is used as a raw material in organic synthesis. It also serves as a pharmaceutical intermediate.
Smuszkiewicz, A.; López-Sanz, J.; Pérez-Mayoral, E.; Soriano, E.; Sobczak, I.; Ziolek, M. ; Martín-Aranda, R. M.; López-Peinado, A. J. Amino-grafted mesoporous materials based on MCF structure involved in the quinoline synthesis. Mechanistic insights. J. Mol. Catal. A: Chem. 2013, 378, 38-46.
Smuszkiewicz, A.; Pérez-Mayoral, E.; Soriano, E.; Sobczak, I.; Ziolek, M.; Martín-Aranda, R. M.; López-Peinado, A. J. Bifunctional mesoporous MCF materials as catalysts in the Friedländer condensation. Catal. Today 2013, 218-219, 70-75.
Nammalwar, B.; Murie, M.; Fortenberry, C.; Bunce,R. A. Quinoline- and 1,8-naphthyridine-3-carboxylic acids using a self-catalyzed Friedländer approach. Tetrahedron Lett. 2014, 55 (20), 3181-3183.
Gouda, M. A.; Sabah, M. A.; Aljuhani, W. K.; El-Gahani, A. S.; El-Enazi, S. A. E.; Al Enizi, S. A.; Al-Balawi, M. M. Utility of 2-cyano-N-(2-hydroxyethyl) acetamide in heterocyclic synthesis. Eur. J. Chem.2015, 6 (2), 219-224.
Hazard Statements: H315-H319-H335
Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.
Precautionary Statements: P264b-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P362-P501c
Wash face, hands and any exposed skin thoroughly after handling Use only outdoors or in a well-ventilated area. Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN: Wash with plenty of soap and water. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Call a POISON CENTER or doctor/physician if you feel unwell. If skin irritation occurs: Get medical advice/attention. Take off contaminated clothing and wash before reuse. Dispose of contents/ container to an approved waste disposal plant