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3405-77-4 - 5-Methylisoxazole-3-carboxylic acid, 98+% - L17577 - Alfa Aesar

L17577 5-Methylisoxazole-3-carboxylic acid, 98+%

CAS Number
3405-77-4
Synonyms

Size Price ($) Quantity Availability
5g 46.53
25g 172.01
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5-Methylisoxazole-3-carboxylic acid, 98+%

MDL
MFCD01318162
EINECS
222-289-4

Chemical Properties

Formula
C5H5NO3
Formula Weight
127.10
Melting point
171-173°

Applications

It is a reactant for Click/aza-Michael or Click/oligomeric alkyl carbodiimide esterification reactions, preparation of aminopyrazole amide derivatives as Raf kinase inhibitors in melanoma cells and preparation of trifluoromethoxyphenyl(thiazolyl)pyrroles and other heterocycle-bearing polyfunctionalized pyrroles via chain heterocyclization.

Notes

Store at room temperature. Keep away from strong oxidizing agents.

Literature References

B. Chandrakantha.; Prakash Shetty.; Vijesh Nambiyar.; Nishitha Isloor.; Arun M. Isloor. Synthesis, characterization and biological activity of some new 1,3,4-oxadiazole bearing 2-flouro-4-methoxy phenyl moiety.European Journal of Medicinal Chemistry. 2010, 45 (3),1206-1210 .

Peter S. Dragovich.; Thomas J. Prins.; Ru Zhou.; Theodore O. Johnson.; Edward L. Brown.; Fausto C. Maldonado.; Shella A. Fuhrman.; Leora S. Zalman.; Amy K. Patick.; David A. Matthews.; Xinjun Hou.; James W. Meador III.; Rose Ann Ferr.; Stephen T. Worland. Structure-Based Design, Synthesis, and Biological Evaluation of Irreversible Human Rhinovirus 3C Protease Inhibitors. Part 7: Structure-Activity Studies of Bicyclic 2-Pyridone-Containing Peptidomimetics.Bioorg. Med. Chem. Lett. . 2002, 12 (5),733-738 .

GHS Hazard and Precautionary Statements

Hazard Statements: H315-H319-H335

Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Precautionary Statements: P261-P280-P305+P351+P338-P304+P340-P362-P312-P321-P405-P403+P233-P501a

Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Take off contaminated clothing and wash before reuse. Call a POISON CENTER or doctor/physician if you feel unwell. Specific treatment (see label). Store locked up. Store in a well-ventilated place. Keep container tightly closed. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Beilstein
114094
Harmonized Tariff Code
2934.99
TSCA
No

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