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112275-50-0 - 1-Boc-homopiperazine, 98% - 1-(tert-Butoxycarbonyl)homopiperazine - tert-Butyl hexahydro-1,4-diazepine-1-carboxylate - L17728 - Alfa Aesar

L17728 1-Boc-homopiperazine, 98%

CAS Number
112275-50-0
Synonyms
1-(tert-Butoxycarbonyl)homopiperazine
tert-Butyl hexahydro-1,4-diazepine-1-carboxylate

Size Price ($) Quantity Availability
1g 36.18
5g 113.30
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1-Boc-homopiperazine, 98%

MDL
MFCD00276987

Chemical Properties

Formula
C10H20N2O2
Formula Weight
200.28
Boiling Point
90°/0.5mm
Flash Point
>110°(230°F)
Density
1.016
Refractive Index
1.4710
Sensitivity
Air Sensitive
Solubility
Not miscible or difficult to mix in water.

Applications

1-Boc-homopiperazine is used in synthesis of potent anticoagulant. It is also used to produce 4-(7,8,9,10-tetrahydro-6H-cyclohepta[b]quinolin-11-yl)-[1,4]diazepane-1-carboxylic acid tert-butyl ester by reaction with 11-bromo-7,8,9,10-tetrahydro-6H-cyclohepta[b]quinoline.

Notes

Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Store under inert gas. It is sensitive to air.

Literature References

Hiroyuki Koshio.; Fukushi Hirayama.; Tsukasa Ishihara.; Yuta Taniuchi.; Kazuo Sato.; Yumiko Sakai-Moritani.; Seiji Kaku.; Tomihisa Kawasaki.; Yuzo Matsumoto.; Shuichi Sakamoto.; Shin-ichi Tsukamoto. Synthesis and biological activity of novel 1,4-diazepane derivatives as factor Xa inhibitor with potent anticoagulant and antithrombotic activity. Bioorganic & Medicinal Chemistry. 2004, 12 (9), 2179-2191.

Saito, K.; Nakao, A.; Shinozuka, T.; Shimada, K.; Matsui, S.; Oizumi, K.; Naito, S. Discovery and structure-activity relationship of thienopyridine derivatives as bone anabolic agents. Bioorganic & medicinal chemistry. 2013, 21 (7), 1628-1642.

GHS Hazard and Precautionary Statements

Hazard Statements: H314-H318

Causes severe skin burns and eye damage. Causes serious eye damage.

Precautionary Statements: P280-P305+P351+P338-P309-P310

Wear protective gloves/protective clothing/eye protection/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF exposed or if you feel unwell: Immediately call a POISON CENTER or doctor/physician.

Other References

Beilstein
7581789
Hazard Class
8
Packing Group
III
Harmonized Tariff Code
2933.99
TSCA
No

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