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7-Bromo-1-hydroxyisoquinoline acts as a pharmaceutical intermediate. It is also used to prepare 1-amino-4-bromoisoquinoline.
Ndubaku, C. O.; Crawford, T. D.; Chen, H.; Boggs, J. W.; Drobnick, J.; Harris, S. F.; Jesudason, R.; McNamara, E.; Nonomiya, J.; Sambrone, A.; Schmidt, S.; Smyczek, T.; Vitorino, P.; Wang, L.; Wu, P.; Yeung, S.; Chen, J.; Chen, K.; Ding, C. Z.; Wang, T.; Xu, Z.; Gould, S. E.; Murray, L. J.; Ye, W. Structure-Based Design of GNE-495, a Potent and Selective MAP4K4 Inhibitor with Efficacy in Retinal Angiogenesis. ACS Med. Chem. Lett. 2015, 6 (8), 913-918.
Tikad, A.; Akssira, M.; Massip, S.; Léger, J. M.; Jarry, C.; Guillaumet, G.; Routier, S. Regiocontroled SNAr and Palladium Cross-Coupling Reactions of 2,4,7-Trichloropyrido[3,2-d]pyrimidine. Eur. J. Org. Chem. 2012, 2012 (24), 4523-4532.
Price, D. A.; James, K.; Osborne, S.; Harbottle, G. W. Selective fluorination of 1-hydroxyisoquinolines using Selectfluor. Tetrahedron Lett. 2007, 48 (41), 7371-7373.
Hazard Statements: H315-H319-H335
Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.
Precautionary Statements: P261-P280a-P305+P351+P338-P304+P340-P405-P501a
Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves and eye/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.