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223671-15-6 - 7-Bromo-1-hydroxyisoquinoline, 98+% - 7-Bromoisocarbostyril - L17800 - Alfa Aesar

L17800 7-Bromo-1-hydroxyisoquinoline, 98+%

CAS Number
223671-15-6
Synonyms
7-Bromoisocarbostyril

Size Price ($) Quantity Availability
1g 91.05
5g 270.40
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7-Bromo-1-hydroxyisoquinoline, 98+%

MDL
MFCD02093963
EINECS
000-000-0

Chemical Properties

Formula
C9H6BrNO
Formula Weight
224.06
Melting point
248-250°
Solubility
Slightly soluble in water.

Applications

7-Bromo-1-hydroxyisoquinoline acts as a pharmaceutical intermediate. It is also used to prepare 1-amino-4-bromoisoquinoline.

Notes

Incompatible with strong oxidizing agents.

Literature References

Ndubaku, C. O.; Crawford, T. D.; Chen, H.; Boggs, J. W.; Drobnick, J.; Harris, S. F.; Jesudason, R.; McNamara, E.; Nonomiya, J.; Sambrone, A.; Schmidt, S.; Smyczek, T.; Vitorino, P.; Wang, L.; Wu, P.; Yeung, S.; Chen, J.; Chen, K.; Ding, C. Z.; Wang, T.; Xu, Z.; Gould, S. E.; Murray, L. J.; Ye, W. Structure-Based Design of GNE-495, a Potent and Selective MAP4K4 Inhibitor with Efficacy in Retinal Angiogenesis. ACS Med. Chem. Lett. 2015, 6 (8), 913-918.

Tikad, A.; Akssira, M.; Massip, S.; Léger, J. M.; Jarry, C.; Guillaumet, G.; Routier, S. Regiocontroled SNAr and Palladium Cross-Coupling Reactions of 2,4,7-Trichloropyrido[3,2-d]pyrimidine. Eur. J. Org. Chem. 2012, 2012 (24), 4523-4532.

Price, D. A.; James, K.; Osborne, S.; Harbottle, G. W. Selective fluorination of 1-hydroxyisoquinolines using Selectfluor. Tetrahedron Lett. 2007, 48 (41), 7371-7373.

GHS Hazard and Precautionary Statements

Hazard Statements: H315-H319-H335

Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Precautionary Statements: P261-P280-P305+P351+P338-P304+P340-P362-P312-P321-P405-P403+P233-P501a

Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Take off contaminated clothing and wash before reuse. Call a POISON CENTER or doctor/physician if you feel unwell. Specific treatment (see label). Store locked up. Store in a well-ventilated place. Keep container tightly closed. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Beilstein
8405244
Harmonized Tariff Code
2933.49
TSCA
No

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