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L17831 1-Chloroisoquinoline, 95%

CAS Number
19493-44-8
Synonyms

Stock No. Size Price ($) Quantity Availability
L17831-03 1g 32.00
L17831-06 5g 105.00
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1-Chloroisoquinoline, 95%

MDL
MFCD00024134

Chemical Properties

Formula
C9H6ClN
Formula Weight
163.61
Melting point
33-35°
Boiling Point
105-108°/4mm
Flash Point
>110°(230°F)
Storage & Sensitivity
Ambient temperatures.
Solubility
Insoluble in water.

Applications

The product has been used in a Mn-catalyzed cross-coupling with aryl- and alkylmagnesium halides. It has also been used in a Pd-catalyzed cross-coupling with heteroaryl boronic acids and esters. Furthermore, it has been used in a homocoupling reaction to yield bis-isoquinoline, each enantiomer of which might be very useful as a chiral ligand for asymmetric synthesis. 1-Chloroisoquinone is used in the preparation of new aminoisoquinolinylurea derivatives which show antiproliferative activity against melanoma cell lines. It can also be applied to the control of storage age and stability of unstable boronic acids.

Notes

Store away from oxidizing agents. Keep the container tightly closed and place it in a cool, dry and well ventilated condition.

Literature References

Kelvin Billingsley and Stephen L Buchwald. Highly efficient monophosphine-based catalyst for the palladium-catalyzed suzuki-miyaura reaction of heteroaryl halides and heteroaryl boronic acids and esters.J. Am. Chem. Soc.,2007,129(11), 3358-3366.

Chang, et al. Homocoupling of aryl iodides and bromides using a palladium/indium bimetallic system.Synth. Commun.,2005,35(13), 1851-1857.

GHS Hazard and Precautionary Statements

Hazard Statements: H302-H312-H315-H319-H335

Harmful if swallowed. Harmful in contact with skin. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Precautionary Statements: P261-P264b-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P312-P330-P332+P313-P337+P313-P362-P501c

Avoid breathing dust/fume/gas/mist/vapours/spray. Wash face, hands and any exposed skin thoroughly after handling Do not eat, drink or smoke when using this product. Use only outdoors or in a well-ventilated area. Wear protective gloves/protective clothing/eye protection/face protection. IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. IF ON SKIN: Wash with plenty of soap and water. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Rinse mouth. If skin irritation occurs: Get medical advice/attention. If eye irritation persists: Take off contaminated clothing and wash before reuse. Dispose of contents/ container to an approved waste disposal plant

Other References

Beilstein
2996
Harmonized Tariff Code
2933.49
TSCA
No

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