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5856-77-9 - 2,2-Dimethylbutyryl chloride, 98% - L18125 - Alfa Aesar

L18125 2,2-Dimethylbutyryl chloride, 98%

CAS Number
5856-77-9
Synonyms

Size Price ($) Quantity Availability
10g 32.96
50g 92.08
250g 230.40
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2,2-Dimethylbutyryl chloride, 98%

MDL
MFCD03093071
EINECS
227-478-5

Chemical Properties

Formula
C6H11ClO
Formula Weight
134.61
Boiling Point
133°
Flash Point
29°(84°F)
Density
0.980
Refractive Index
1.4240
Sensitivity
Moisture Sensitive
Solubility
Reacts with water. Soluble in chloroform and ethyl acetate.

Applications

,2-Dimethylbutanoyl chloride is a reagent that is used in the synthesis of 4α,5-Dihydro Simvastatin, the drug, is sold under the trade name Zocor. A competitive inhibitor of HMG-CoA reductase. A synthetic analog of Lovastatin. Antilipemic.

Notes

Moisture sensitive. Store away from water/moisture, strong bases and oxidizing agents. Keep the container tightly closed and place it in a cool, dry and well ventilated condition. Store under inert gas. Keep ignition sources away. Protect from electrostatic charges.

Literature References

W. F. Hoffman, et al. 3-Hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors. 4. Side-chain ester derivatives of mevinolin.J. Med. Chem.,1986,29(5), 849-852.

G. E. Stokker, et al. 3-Hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors. 5. 6-(Fluoren-9-yl)- and 6-(fluoren-9-ylidene)-3,5-dihydroxyhexanoic acids and their lactone derivatives.J. Med. Chem.,1986,29(5), 852-855.

GHS Hazard and Precautionary Statements

Hazard Statements: H314-H318-H226

Causes severe skin burns and eye damage. Causes serious eye damage. Flammable liquid and vapour.

Precautionary Statements: P210-P260-P280-P303+P361+P353-P305+P351+P338-P301+P330+P331-P304+P340-P310-P405-P501a

Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Do not breathe dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Immediately call a POISON CENTER or doctor/physician. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Beilstein
1743935
Hazard Class
8
Packing Group
II
Harmonized Tariff Code
2915.90
TSCA
No

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