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L19068 Harmine, 98+%

CAS Number
442-51-3
Synonyms
6-Methoxyharmane
7-Methoxy-1-methyl-9H-pyrido[3,4-b]indole

Stock No. Size Price ($) Quantity Availability
L19068-MD 250mg 40.80
L19068-03 1g 93.60
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Harmine, 98+%

MDL
MFCD00004958
EINECS
207-131-4

Chemical Properties

Formula
C13H12N2O
Formula Weight
212.25
Melting point
262-266°
Storage & Sensitivity
Ambient temperatures.
Solubility
Soluble in DMSO (100 mM), DMF (~1.5 mg/ml), ethanol (~1.5 mg/ml), and PBS (pH 7.2, ~0.25 mg/ml). Insoluble in water.

Applications

Harmine, inhibits the Wnt signaling pathway in a cell-specific manner. Down-regulates inflammatory gene expression (TNF-α, IL-1β, iNOS). Reversibly inhibits MAO-A (monoamine oxidase A) but has no effect on MAO-B. Harmine is an inhibitor of Dyrk1A, Dyrk2 and Dyrk3.

Notes

Keep container tightly closed in a dry and well-ventilated place. Keep away from oxidizing agents. Stable under recommended storage conditions.

Literature References

HM Zonderland.; EG Coerkamp.; J Hermans. Diagnosis of Breast Cancer: Contribution of US as an Adjunct to Mammography 1. Radiology. 1999 213 (2), 255-300.

M Kriege.; C Brekelmans.; C Boetes.; SH Muller. Differences between first and subsequent rounds of the MRISC breast cancer screening program for women with a familial or genetic predisposition. Cancer. 2006 106 (11), 2318-2326.

GHS Hazard and Precautionary Statements

Hazard Statements: H302+H312+H332-H319

Harmful if swallowed. Harmful in contact with skin. Harmful if inhaled. Causes serious eye irritation.

Precautionary Statements: P261-P264b-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P312-P330-P337+P313-P363-P501c

Avoid breathing dust/fume/gas/mist/vapours/spray. Wash face, hands and any exposed skin thoroughly after handling Do not eat, drink or smoke when using this product. Use only outdoors or in a well-ventilated area. Wear protective gloves/protective clothing/eye protection/face protection. IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. IF ON SKIN: Wash with plenty of soap and water. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Rinse mouth. If eye irritation persists: Get medical advice/attention. Wash contaminated clothing before reuse. Dispose of contents/ container to an approved waste disposal plant

Other References

Merck
14,4616
Beilstein
178813
Hazard Class
6.1
Packing Group
III
Harmonized Tariff Code
2939.79
TSCA
No
RTECS
UV0175000

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