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442-51-3 - Harmine, 98+% - 6-Methoxyharmane - 7-Methoxy-1-methyl-9H-pyrido[3,4-b]indole - L19068 - Alfa Aesar

L19068 Harmine, 98+%

CAS Number
442-51-3
Synonyms
6-Methoxyharmane
7-Methoxy-1-methyl-9H-pyrido[3,4-b]indole

Size Price ($) Quantity Availability
250mg 37.08
1g 97.20
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Harmine, 98+%

MDL
MFCD00004958
EINECS
207-131-4

Chemical Properties

Formula
C13H12N2O
Formula Weight
212.25
Melting point
262-266°
Solubility
Soluble in DMSO (100 mM), DMF (~1.5 mg/ml), ethanol (~1.5 mg/ml), and PBS (pH 7.2, ~0.25 mg/ml). Insoluble in water.

Applications

Harmine, inhibits the Wnt signaling pathway in a cell-specific manner. Down-regulates inflammatory gene expression (TNF-α, IL-1β, iNOS). Reversibly inhibits MAO-A (monoamine oxidase A) but has no effect on MAO-B. Harmine is an inhibitor of Dyrk1A, Dyrk2 and Dyrk3.

Notes

Keep container tightly closed in a dry and well-ventilated place. Keep away from oxidizing agents. Stable under recommended storage conditions.

Literature References

HM Zonderland.; EG Coerkamp.; J Hermans. Diagnosis of Breast Cancer: Contribution of US as an Adjunct to Mammography 1. Radiology. 1999 213 (2), 255-300.

M Kriege.; C Brekelmans.; C Boetes.; SH Muller. Differences between first and subsequent rounds of the MRISC breast cancer screening program for women with a familial or genetic predisposition. Cancer. 2006 106 (11), 2318-2326.

GHS Hazard and Precautionary Statements

Hazard Statements: H302-H332-H319

Harmful if swallowed. Harmful if inhaled. Causes serious eye irritation.

Precautionary Statements: P280h-P305+P351+P338

Wear protective gloves/clothing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

Other References

Merck
14,4616
Beilstein
178813
Harmonized Tariff Code
2933.99
TSCA
No
RTECS
UV0175000

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