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68957-94-8 - 1-Propylphosphonic acid cyclic anhydride, 50+% soln. in DMF - 1-Propanephosphonic acid cyclic anhydride - T3P - L19271 - Alfa Aesar

L19271 1-Propylphosphonic acid cyclic anhydride, 50+% soln. in DMF

CAS Number
68957-94-8
Synonyms
1-Propanephosphonic acid cyclic anhydride
T3P

Size Price ($) Quantity Availability
10g 36.60
50g 152.00
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1-Propylphosphonic acid cyclic anhydride, 50+% soln. in DMF

MDL
MFCD00006583
EINECS
422-210-5

Chemical Properties

Formula
C9H21O6P3
Formula Weight
318.19
Boiling Point
153°
Flash Point
62°(143°F)
Density
1.090
Refractive Index
1.4505
Sensitivity
Moisture Sensitive
Solubility
Miscible with dichloromethane, dioxane, terahydrofuran, polar and aprotic organic solvents.

Applications

1-Propylphosphonic acid cyclic anhydride is used in the synthesis of N-acyloxythiazole-2(3H)-thiones. It is also used to promote the synthesis of hydroxamic acids from carboxylic acids. Further, it is employed as an efficient promoter for the Lossen rearrangement to synthesis urea and carbamate derivatives.

Notes

Moisture sensitive. Incompatible withstrong oxidizing agents.

Literature References

T3P is a registered trademark of Archimica.

For use in the synthesis of N-acyloxythiazole-2(3H)-thiones, see: Synlett, 371 (2000).

Augustine, J. K.; Kumar, R.; Bombrun, A.; Mandal, A. B. An efficient catalytic method for the Beckmann rearrangement of ketoximes to amides and aldoximes to nitriles mediated by propylphosphonic anhydride (T3P®). Tetrahedron Lett. 2011, 52 (10), 1074-1077.

Augustine, J. K.; Bombrun, A.; Ramappa, B.; Boodappa, C. An efficient one-pot synthesis of coumarins mediated by propylphosphonic anhydride (T3P) via the Perkin condensation. Tetrahedron Lett. 2012, 53 (33), 4422-4425.

GHS Hazard and Precautionary Statements

Hazard Statements: H360-H314-H302-H332-H227

May damage fertility or the unborn child. Causes severe skin burns and eye damage. Harmful if swallowed. Harmful if inhaled. Combustible liquid.

Precautionary Statements: P210-P260-P201-P261-P280-P303+P361+P353-P305+P351+P338-P301+P330+P331-P405-P501a

Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Do not breathe dust/fume/gas/mist/vapours/spray. Obtain special instructions before use. Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Beilstein
5079255
Hazard Class
8
Packing Group
II
Harmonized Tariff Code
2934.99
TSCA
No

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