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2-Bromo-4-fluorobenzoic acid is used in the synthesis of 3-fluoro-8-(methylthio)dibenzo[b,f]thiepin-10(11H)-one, 2-fluoro-8-(methylthio)dibenzo[b,f]thiepin-10(11H)-one, 2-((2-carboxy-5-fluorophenyl)amino)-3-methoxybenzoic acid and 2-bromo-4-fluorobenzamide. It is also used in the preparation of boron-containing anti-fungal agents, in the treatment of onychomycosis.
Lauren R Donaldson.; Stephen Wallace.; David Haigh.; E Elizabeth Patton.; Alison N Hulme. Rapid synthesis and zebrafish evaluation of a phenanthridine-based small molecule library. Organic & Biomolecular Chemistry. 2011, 9 (7), 2233-2239.
Christian Wolf.; Shuanglong Liu.; Xuefeng Mei.; Adam T August.; Michael D Casimir. Regioselective copper-catalyzed amination of bromobenzoic acids using aliphatic and aromatic amines. Journal of Organic Chemistry. 2006, 71 (8), 3270-3273.
Hazard Statements: H315-H319-H335
Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.
Precautionary Statements: P261-P280a-P305+P351+P338-P304+P340-P405-P501a
Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves and eye/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.