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Efficient peptide coupling agent for N-methylated amino esters for which coupling with a number of conventional reagents has proved ineffective or slow, and giving superior results to 1H-Benzotriazol-1-yloxytri(1-pyrrolidinyl)phosphonium hexafluorophosphate, B25251, in this type of reaction: J. Org. Chem., 59, 2437 (1994). See Appendix 6./n
Can also be used to activate formamides, e.g. reaction of DMF with primary amines to yield formamidines: Tetrahedron Lett., 40, 5487 (1999)./n
Hazard Statements: H315-H319-H335
Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.
Precautionary Statements: P261-P280a-P305+P351+P338-P304+P340-P405-P501a
Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves and eye/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.