Triphenylphosphine is used as a support for nickel, rhenium and rhodium in hydrogenation, in dimerization of alkenes and in hydroformylation. It is also used for the halogenation of carboxylic acid and alkanes in carbon tetrachloride, addition of iodine in DMF esterifies primary and secondary alcohols to their respective formate esters and in the Mitsunobu and the Wittig reactions.
T.A. Stephenson.; G. Wilkinson. New complexes of ruthenium (II) and (III) with triphenylphosphine, triphenylarsine, trichlorostannate, pyridine and other ligands. Journal of Inorganic and Nuclear Chemistry. 1966, 28 (4), 945-956.
Mitsuru Kato.; Masami Kamigaito.; Mitsuo Sawamoto.; Toshinobu Higashimura. Polymerization of Methyl Methacrylate with the Carbon Tetrachloride/Dichlorotris-(triphenylphosphine)ruthenium(II)/Methylaluminum Bis(2,6-di-tert-butylphenoxide) Initiating System: Possibility of Living Radical Polymerization. Macromolecules. 1995, 28 (5), 1721-1723.
Support for nickel, rhenium and rhodium in hydrogenation: J. Am. Chem. Soc., 97, 1742 (1975); dimerization of alkenes: J. Am. Chem. Soc., 97, 341 (1974) and hydroformylation: J. Am. Chem. Soc., 98 5402 (1976). For the halogenation of carboxylic acid and alkanes in carbon tetrachloride: Synthesis, 1093 (1992). Addition of iodine in DMF esterifies primary and secondary alcohols to their respective formate esters: Med. Res. Rev., 19, 97 (1999).
For use in the Mitsunobu reaction: Tetrahedron Lett., 8751 (1998), and the Wittig reaction: J. Org. Chem., 48, 326 (1983); J. Chem. Soc. Perkin 1, 2243 (1998).
Hazard Statements: H302-H317
Harmful if swallowed. May cause an allergic skin reaction.
Precautionary Statements: P261-P280g-P301+P312a-P363-P321-P501a
Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves. IF SWALLOWED: Wash contaminated clothing before reuse. Specific treatment (see label). Dispose of contents/container in accordance with local/regional/national/international regulations.