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L19499 (R)-(+)-3-Hydroxypyrrolidine, 99%, ee 99%

CAS Number
2799-21-5
Synonyms
(R)-(+)-3-Pyrrolidinol

Stock No. Size Price ($) Quantity Availability
L19499-03 1g 58.70
L19499-06 5g 187.00
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(R)-(+)-3-Hydroxypyrrolidine, 99%, ee 99%

MDL
MFCD00145220

Chemical Properties

Formula
C4H9NO
Formula Weight
87.12
Melting point
15°
Boiling Point
108-110°/8mm
Flash Point
>110°(230°F)
Density
1.048
Refractive Index
1.4900
Storage & Sensitivity
Air Sensitive. Hygroscopic. Ambient temperatures.
Solubility
Soluble in water and methanol.

Applications

(R)-(+)-3-Hydroxypyrrolidine is used in the enantioselective addition of diethylzinc to aromatic aldehydes leading to optically active secondary alcohols. Also used to prepare-κ-opioid receptor agonists.

Notes

Store under inert gas. It is sensitive to moisture. Store in a cool, dry conditions in well sealed containers. It is hygroscopic and sensitive to air. Incompatible with oxidizing agents.

Literature References

A Naylor.; D B Judd.; D I Scopes.; A G Hayes.; P J Birch. 4-[(Alkylamino)methyl]furo[3,2-c]pyridines: a new series of selective kappa-receptor agonists. Journal of Medicinal Chemistry. 1994, 37 (14), 2138-2144.

Mitsunori Hashimoto.; Yutaka Eda.; Yasutomo Osanai.; Toshiaki Iwai.; Seiichi Aoki. A Novel Decarboxylation of α-amino acids. A Facile Method of Decarboxylation by the use of 2-Cyclohexen-1-one as a Catalyst. Chemistry Letters. 1986, 15 (6), 893-896.

Product of Toray Industries, Inc.

GHS Hazard and Precautionary Statements

Hazard Statements: H315-H319-H335

Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Precautionary Statements: P264b-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P362-P501c

Wash face, hands and any exposed skin thoroughly after handling Use only outdoors or in a well-ventilated area. Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN: Wash with plenty of soap and water. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Call a POISON CENTER or doctor/physician if you feel unwell. If skin irritation occurs: Get medical advice/attention. Take off contaminated clothing and wash before reuse. Dispose of contents/ container to an approved waste disposal plant

Other References

Beilstein
5376132
Harmonized Tariff Code
2933.99
TSCA
No

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