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2,4,5-Trichloropyrimidine is used in the synthesis of potent and selective anaplastic lymphoma kinase (ALK-5) inhibitors, used as an anti-tumor treatment. It is also used in the synthesis of EGFR inhibitors.
Richard Ducray.; Pascal Boutron.; Myriam Didelot.; Hervé Germain.; Franck Lach.; Maryannick Lamorlette.; Antoine Legriffon.; Mickael Maudet.; Morgan Ménard.; Georges Pasquet.; Fabrice Renaud.; Iain Simpson.; Gail L. Young. A versatile route to 3-(pyrimidin-4-yl)-imidazo[1,2-a]pyridines and 3-(pyrimidin-4-yl)-pyrazolo[1,5-a]pyridines. Tetrahedron Letters. 2010, 51 (36), 4755-4758.
Eugen F. Mesaros.; Jason P. Burke.; Jonathan D. Parrish.; Benjamin J. Dugan.; Andrew V. Anzalone.; Thelma S. Angeles.; Mark S. Albom.; Lisa D. Aimone.; Matthew R. Quail.; Weihua Wan.; Lihui Lu.; Zeqi Huang.; Mark A. Ator.; Bruce A. Ruggeri.; Mangeng Cheng.; Gregory R. Ott.; Bruce D. Dorsey. Novel 2,3,4,5-tetrahydro-benzo[d]azepine derivatives of 2,4-diaminopyrimidine, selective and orally bioavailable ALK inhibitors with antitumor efficacy in ALCL mouse models. Bioorganic & Medicinal Chemistry Letters. 2011, 21 (1), 463-466.
Hazard Statements: H315-H319-H335
Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.
Precautionary Statements: P261-P264b-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P362-P501c
Avoid breathing dust/fume/gas/mist/vapours/spray. Wash face, hands and any exposed skin thoroughly after handling Use only outdoors or in a well-ventilated area. Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN: Wash with plenty of soap and water. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Call a POISON CENTER or doctor/physician if you feel unwell. If skin irritation occurs: Get medical advice/attention. Take off contaminated clothing and wash before reuse. Dispose of contents/ container to an approved waste disposal plant