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5750-76-5 - 2,4,5-Trichloropyrimidine, 98% - L19506 - Alfa Aesar

L19506 2,4,5-Trichloropyrimidine, 98%

CAS Number
5750-76-5
Synonyms

Size Price ($) Quantity Availability
1g 28.44
5g 122.57
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2,4,5-Trichloropyrimidine, 98%

MDL
MFCD03788200
EINECS
000-000-0

Chemical Properties

Formula
C4HCl3N2
Formula Weight
183.43
Boiling Point
84°/1mm
Flash Point
>110°(230°F)
Density
1.600
Refractive Index
1.5730
Solubility
Not miscible or difficult to mix in water.

Applications

2,4,5-Trichloropyrimidine is used in the synthesis of potent and selective anaplastic lymphoma kinase (ALK-5) inhibitors, used as an anti-tumor treatment. It is also used in the synthesis of EGFR inhibitors.

Notes

Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Incompatible with oxidizing agents.

Literature References

Richard Ducray.; Pascal Boutron.; Myriam Didelot.; Hervé Germain.; Franck Lach.; Maryannick Lamorlette.; Antoine Legriffon.; Mickael Maudet.; Morgan Ménard.; Georges Pasquet.; Fabrice Renaud.; Iain Simpson.; Gail L. Young. A versatile route to 3-(pyrimidin-4-yl)-imidazo[1,2-a]pyridines and 3-(pyrimidin-4-yl)-pyrazolo[1,5-a]pyridines. Tetrahedron Letters. 2010, 51 (36), 4755-4758.

Eugen F. Mesaros.; Jason P. Burke.; Jonathan D. Parrish.; Benjamin J. Dugan.; Andrew V. Anzalone.; Thelma S. Angeles.; Mark S. Albom.; Lisa D. Aimone.; Matthew R. Quail.; Weihua Wan.; Lihui Lu.; Zeqi Huang.; Mark A. Ator.; Bruce A. Ruggeri.; Mangeng Cheng.; Gregory R. Ott.; Bruce D. Dorsey. Novel 2,3,4,5-tetrahydro-benzo[d]azepine derivatives of 2,4-diaminopyrimidine, selective and orally bioavailable ALK inhibitors with antitumor efficacy in ALCL mouse models. Bioorganic & Medicinal Chemistry Letters. 2011, 21 (1), 463-466.

GHS Hazard and Precautionary Statements

Hazard Statements: H314-H318

Causes severe skin burns and eye damage. Causes serious eye damage.

Precautionary Statements: P260-P280-P303+P361+P353-P305+P351+P338-P301+P330+P331-P304+P340-P310-P363-P405-P501a

Do not breathe dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Immediately call a POISON CENTER or doctor/physician. Wash contaminated clothing before reuse. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Beilstein
4449
Hazard Class
8
Packing Group
III
Harmonized Tariff Code
2933.59
TSCA
No

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