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2,4,5-Trichloropyrimidine is used in the synthesis of potent and selective anaplastic lymphoma kinase (ALK-5) inhibitors, used as an anti-tumor treatment. It is also used in the synthesis of EGFR inhibitors.
Richard Ducray.; Pascal Boutron.; Myriam Didelot.; Hervé Germain.; Franck Lach.; Maryannick Lamorlette.; Antoine Legriffon.; Mickael Maudet.; Morgan Ménard.; Georges Pasquet.; Fabrice Renaud.; Iain Simpson.; Gail L. Young. A versatile route to 3-(pyrimidin-4-yl)-imidazo[1,2-a]pyridines and 3-(pyrimidin-4-yl)-pyrazolo[1,5-a]pyridines. Tetrahedron Letters. 2010, 51 (36), 4755-4758.
Eugen F. Mesaros.; Jason P. Burke.; Jonathan D. Parrish.; Benjamin J. Dugan.; Andrew V. Anzalone.; Thelma S. Angeles.; Mark S. Albom.; Lisa D. Aimone.; Matthew R. Quail.; Weihua Wan.; Lihui Lu.; Zeqi Huang.; Mark A. Ator.; Bruce A. Ruggeri.; Mangeng Cheng.; Gregory R. Ott.; Bruce D. Dorsey. Novel 2,3,4,5-tetrahydro-benzo[d]azepine derivatives of 2,4-diaminopyrimidine, selective and orally bioavailable ALK inhibitors with antitumor efficacy in ALCL mouse models. Bioorganic & Medicinal Chemistry Letters. 2011, 21 (1), 463-466.
Hazard Statements: H314-H318
Causes severe skin burns and eye damage. Causes serious eye damage.
Precautionary Statements: P260u-P303+P361+P353-P305+P351+P338-P301+P330+P331-P405-P501a
IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.