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Lithiation with n-BuLi/LiOCH2CH2NMe2 takes place at the 6-position, affording access to 6-substituted derivatives. With LiTMP . It is a building block in heterocycle synthesis.
Vladimir I Tyvorskii.; Denis N Bobrov.; Oleg G Kulinkovich.; Kourosch Abbaspour Tehranib.; Norbert De Kimpe. Synthesis of 5-alkyl-4-amino-2-(trifluoromethyl)pyridines and their transformation into trifluoromethylated 1H-pyrazolo[4,3-c]pyridines.Tetrahedron. 2001, 57 (10),2051-2055 .
Vladimir I Tyvorskii.; Denis N Bobrov.; Oleg G Kulinkovic.; Wim Aelterman.; Norbert De Kimpe. Synthesis of 3-(Trifluoromethyl)benzo[c][1,6]naphthyridines from Substituted 4H-Pyran-4-ones via 4-Amino-5-Aryl-2-(trifluoromethyl)pyridines.Tetrahedron. 2000, 56 (37),7313-7318 .
Lithiation with n-BuLi/LiOCH2CH2NMe2 takes place at the 6-position, affording access to 6-substituted derivatives. With LiTMP (see 2,2,6,6-Tetramethylpiperidine, A18712), 3-lithiation occurs: Eur. J. Org. Chem., 1569 (2003).
Hazard Statements: H226-H315-H319-H335
Flammable liquid and vapour. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.
Precautionary Statements: P210-P233-P235-P240-P241-P242-P243-P264b-P271-P280-P303+P361+P353-P304+P340-P305+P351+P338-P312-P332+P313-P363-P370+P378q-P501c
Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Keep container tightly closed. Keep cool. Ground/bond container and receiving equipment. Use explosion-proof electrical/ventilating/lighting/ equipment. Use only non-sparking tools. Take precautionary measures against static discharge. Wash face, hands and any exposed skin thoroughly after handling Use only outdoors or in a well-ventilated area. Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Call a POISON CENTER or doctor/physician if you feel unwell. If skin irritation occurs: Get medical advice/attention. Wash contaminated clothing before reuse. In case of fire: Use CO2, dry chemical, or foam Dispose of contents/ container to an approved waste disposal plant