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71-44-3 - Spermine, 97% - Neuridine - Musculamine - L19562 - Alfa Aesar

L19562 Spermine, 97%

CAS Number
71-44-3
Synonyms
Neuridine
Musculamine

Size Price ($) Quantity Availability
1g 40.17
5g 133.90
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Spermine, 97%

MDL
MFCD00008215
EINECS
200-754-2

Chemical Properties

Formula
C10H26N4
Formula Weight
202.35
Melting point
28-30°
Boiling Point
150°/5mm
Flash Point
>110°(230°F)
Sensitivity
Air Sensitive & Hygroscopic
Solubility
Soluble in chloroform, methanol, water and lower alcohols. Insoluble in ether, benzene and petroleum ether.

Applications

Binds to the polyamine modulatory site of NMDA Spermine is essential for both normal and neoplastic tissue growth. It is involved in the modulation of calcium-dependent immune processes. It plays an important role in cellular proliferation and differentiation as well as inhibits neuronal nitric oxide synthase (nNOS).

Notes

Air sensitive and hygroscopic. Store in a cool place. Incompatible with acids, acid chlorides, acid anhydrides and oxidizing agents.

Literature References

Bailey, D.; Kirby, B. P.; Atkinson, J.; Fixon-Owoo, S.; Henman, M. C.; Shaw, G. G.; Doyle, K. M. Hydroxycinnamic acid amide derivatives of polyamines reverse spermine-induced CNS excitation. Pharmacol. Biochem. Behav. 2015, 133, 57-64.

Mo, H.; Wang, X.; Zhang, Y.; Zhang, G.; Zhang, J.; Ma, Z. Cotton polyamine oxidase is required for spermine and camalexin signalling in the defence response to Verticillium dahliae. Plant J. 2015, 83 (6), 962-975.

GHS Hazard and Precautionary Statements

Hazard Statements: H314-H318

Causes severe skin burns and eye damage. Causes serious eye damage.

Precautionary Statements: P260-P280-P303+P361+P353-P305+P351+P338-P301+P330+P331-P304+P340-P310-P363-P405-P501a

Do not breathe dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Immediately call a POISON CENTER or doctor/physician. Wash contaminated clothing before reuse. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Merck
14,8743
Beilstein
1751791
Hazard Class
8
Packing Group
III
Harmonized Tariff Code
2921.29
TSCA
Yes
RTECS
EJ7175000

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