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L20134 1-Bromo-2-butyne, 98%

CAS Number
3355-28-0
Synonyms

Stock No. Size Price ($) Quantity Availability
L20134-06 5g 105.00
L20134-14 25g 407.00
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1-Bromo-2-butyne, 98%

MDL
MFCD00190233
EINECS
000-000-0

Chemical Properties

Formula
CH3C≡CCH2Br
Formula Weight
132.99
Boiling Point
123-125°
Flash Point
36°(96°F)
Density
1.519
Refractive Index
1.5080
Storage & Sensitivity
Air Sensitive. Ambient temperatures.
Solubility
Miscible with acetonitrile.

Applications

1-Bromo-2-butyne is used in the preparation of six to eight annulated ring compounds in reaction with indoles and pseudopterane (+/-)-Kallolide B, which is a marine natural product. Further, it acts as a precursor in the preparation of axially chiral teranyl compounds, alkylation of L-tryptophan methyl ester, 4-butynyloxybenzene sulfonyl chloride and mono-propargylated diene derivative. In addition to this, it is also used in the synthesis of isopropylbut-2-ynylamine, allenylcyclobutanol derivatives, allyl-[4-(but-2-ynyloxy)phenyl]sulfane, allenylindium and axially chiral teranyl compounds.

Notes

Incompatible with strong oxidizing agents.

Literature References

Wells, S. M.; Brummond, K. M. Conditions for a Rh(I)-catalyzed [2+2+1] cycloaddition reaction with methyl substituted allenes and alkynes. Tetrahedron Lett. 2015, 56 (23), 3546-3549.

Mizoguchi, H.; Watanabe, R.; Minami, S.; Oikawa, H.; Oguri, H. Synthesis of multiply substituted 1,6-dihydropyridines through Cu(I)-catalyzed 6-endo cyclization. Org. Biomol. Chem. 2015, 13 (21), 5955-5963.

GHS Hazard and Precautionary Statements

Hazard Statements: H226-H315-H319-H335

Flammable liquid and vapour. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Precautionary Statements: P210-P233-P235-P240-P241-P242-P243-P264b-P271-P280-P303+P361+P353-P304+P340-P305+P351+P338-P312-P332+P313-P363-P370+P378q-P501c

Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Keep container tightly closed. Keep cool. Ground/bond container and receiving equipment. Use explosion-proof electrical/ventilating/lighting/ equipment. Use only non-sparking tools. Take precautionary measures against static discharge. Wash face, hands and any exposed skin thoroughly after handling Use only outdoors or in a well-ventilated area. Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Call a POISON CENTER or doctor/physician if you feel unwell. If skin irritation occurs: Get medical advice/attention. Wash contaminated clothing before reuse. In case of fire: Use CO2, dry chemical, or foam Dispose of contents/ container to an approved waste disposal plant

Other References

Beilstein
605306
Hazard Class
3
Packing Group
III
Harmonized Tariff Code
2903.39
TSCA
No

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