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4-Chloro-2-butyn-1-ol is used as a precursor to prepare optically active secondary 2,3-allenols by reacting with the corresponding Grignard reagents in presence of CUCN as catalyst. It is utilized as an intermediate in organic synthesis.
Krishnamurthy, V. R.; Dougherty, A.; Haller, C. A.; Chaikof. E. L. Total Synthesis and Bioactivity of 18(R)-Hydroxyeicosapentaenoic Acid. J. Org. Chem. 2011, 76 (13), 5433-5437.
Li, J.; Kong, W.; Fu, C.; Ma, S. An Efficient CuCN-Catalyzed Synthesis of Optically Active 2,3-Allenols from Optically Active 1-Substituted 4-Chloro-2-butyn-1-ols. J. Org. Chem. 2009, 74 (14), 5104-5106.
Hazard Statements: H301-H315-H319-H335
Toxic if swallowed. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.
Precautionary Statements: P261-P280a-P301+P310a-P305+P351+P338-P405-P501a
Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves and eye/face protection. IF SWALLOWED: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.