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58081-05-3 - (R)-(+)-beta-Hydroxy-gamma-butyrolactone, 90+%, ee 97+% - L20255 - Alfa Aesar

L20255 (R)-(+)-beta-Hydroxy-gamma-butyrolactone, 90+%, ee 97+%

CAS Number
58081-05-3
Synonyms

Size Price ($) Quantity Availability
1g 61.90
5g 215.00
25g 836.00
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(R)-(+)-beta-Hydroxy-gamma-butyrolactone, 90+%, ee 97+%

MDL
MFCD00211248

Chemical Properties

Formula
C4H6O3
Formula Weight
102.09
Boiling Point
98-100°/0.3mm
Flash Point
>110°(230°F)
Density
1.302
Refractive Index
1.4655
Solubility
Miscible with ethanol and chloroform.

Applications

(R)-(+)-β-Hydroxy-γ-butyrolactone is used in the pharmaceutical industry as a chiral building block for the statin class of cholesterol-reducing drugs. It is also used to prepare HIV inhibitors and nutritional supplement such as L-carnitine.

Notes

Store in a cool place. Incompatible with strong oxidizing agents.

Literature References

Gade, N. R.; Iqbal, J. A Common Synthetic Protocol for the Cyclic and Acyclic Core of Migrastatin, Isomigrastatin, and Dorrigocin via a Chiral beta-Hydroxy-gamma-butyrolactone Intermediate. Eur. J. Org. Chem. 2014, 2014 (29), 6558-6564.

Blain, J. C.; Ricardo, A.; Szostak, J. W. Synthesis and Nonenzymatic Template-Directed Polymerization of 2'-Amino-2'-deoxythreose Nucleotides. J. Am. Chem. Soc. 2014, 136 (5), 2033-2039.

De Angelis, F.; De Fusco, E.; Desiderio, P.; Giannessi, F.; Piccirilli, F.; Tinti, M. O. Inversion of Configuration of (S)-beta-Hydroxy-gamma-butyrolactone with Total Retention of the Enantiomeric Purity. Eur. J. Org. Chem. 1999, 1999 (11), 2705-2707.

GHS Hazard and Precautionary Statements

Hazard Statements: H315-H319

Causes skin irritation. Causes serious eye irritation.

Precautionary Statements: P280a-P264-P305+P351+P338-P321-P332+P313-P337+P313

Wear protective gloves and eye/face protection. Wash thoroughly after handling. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Specific treatment (see label). If skin irritation occurs: Get medical advice/attention. If eye irritation persists:

Other References

Beilstein
3648447
Harmonized Tariff Code
2932.20
TSCA
No

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