Aryl glyoxals have been used in the formation of 1,5-disubstituted hydantoins and thiohydantoins; J. Heterocycl. Chem., 18, 1651 (1981); the reaction was subsequently reported to be accelerated under solvent-free conditions using microwaves: Synthesis, 75 (2002)./n
Also find extensive use in multi-component reactions to obtain a wide variety of heterocycles including butenolides: Org. Lett., 3, 2875 (2001); oxazoles via a Passerini reaction: Liebigs Ann. Chem., 1107 (1991), and pyrazines via a four-component Ugi reaction: Synthesis, 1553 (2003)./n
Hazard Statements: H315-H319-H335
Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.
Precautionary Statements: P261-P280a-P305+P351+P338-P304+P340-P405-P501a
Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves and eye/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.