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Electrophilic Aromatic Substitution Reactions

electrophilic aromatic substitution  
Named Reactions in Organic Synthesis

Featured named reactions:

 

When an atom attached to an aromatic system gets replaced by an electrophile in a chemical reaction this is known as electrophilic aromatic substitution.  

Within the category of electrophilic aromatic substitution reactions, there are a number of important chemical reactions which are named after their discoverers. Despite being discovered many years ago, these named reactions continue to play a crucial role in organic synthesis, and in constructing ever more complex and diverse chemical molecules.

One of the earliest and perhaps best known of these named reactions are the Friedel-Crafts Alkylation and Acylation Reactions  which are also related to several other classic named reactions in this category.

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In addition, there are a number of other key named electrophilic aromatic substitution reactions: Bischler-Napieralski synthesis, Combes synthesis, Kolbe-Schmitt reaction, Pictet-Spengler synthesis, Pomeranz-Fritsch reaction; Reimer-Tiemann reaction, Vilsmeier-Haack formylation, and Von Pechmann reaction.


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Other reaction categories:
Nucleophilic substitution
Heterocycle formation
Transition metal-catalyzed couplings Oxidation



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