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Hydrazine derivatives are class of organic compounds having the general chemical formula RNHNHR. Hydrazine is an inorganic compound from which hydrazine derivatives are prepared by substituting the hydrogens with suitable substitutions. Monomethylhydrazine (MMH) is a volatile hydrazine used as a rocket propellant.
Hydrazine is a convenient reducing agent and hence used to reduce metal salts and oxides to the pure metals. Hydrazine is also used in nickel. It is also used as an antioxidant, oxygen scavenger, and corrosion inhibitor in water boilers and heating systems. Hydrazine is used in the Wolff-Kishner reduction of converting a ketone into an alkane and as a precursor to blowing agents and as a foaming agent.
Aryl hydrazines are employed to prepare a large variety of indoles via the Fischer Indole Synthesis, which are key intermediates in the synthesis of various dyes and pharmaceuticals. Alkyl and arylhydrazines are useful for generating several heterocycles of pharmacological importance. Arylhydrazines can be used in the resolution of racemic N-protected amino acids. As a practical approach for an array of substituted biaryls, phenylhydrazine can serve as initiator for efficient direct radical arylation of unactivated arenes (See: Dewanji, A.; Murarka, S.; Curran, D. P.; Studer, A. Phenyl Hydrazine as Initiator for Direct Arene CH Arylation via Base Promoted Homolytic Aromatic Substitution. Org. Lett. 2013, 15, 6102-6105).