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Indazoles [1H-Benzopyrazole, 2-Azaindole] are heterocyclic aromatic organic compounds, in which pyrazole is fused with a benzene ring. Pyrazoles are heteroaromatic compounds with two nitrogens in adjacent positions. The presence of two nitrogen sites located in adjacent positions in the molecular structure allows indazole, at low concentrations in mildly acid or basic media, to form 1H and 2H tautomers via acid-base interactions as well as symmetrical dimers by hydrogen bonding.
Indazoles are reported to be generally rare in nature. There are a wide variety of indazole derivatives reported in the synthesis of active pharmaceutical drugs. The indazole derivatives, due to their potent pharmacological activity, have been under investigation in the pharmaceutical field for various therapeutic uses, such as, antibacterial, anticancer, antionidants, anti-inflammatory, antidiabetic, antiviral, atniproliferative, antituberculosis, antispermetogenic activity, and antipsychotic drugs. For example, 3-aminoindazole derivatives have attracted much interest due to their activity against a number of pharmacological targets including kinases, CNS and inflammatory pathways. Substituted 3-aminoindazoles are used as potent, ATP competitive, reversible inhibitors of AKt.