I agree Our site saves small pieces of text information (cookies) on your device in order to deliver better content and for statistical purposes. You can disable the usage of cookies by changing the settings of your browser. By browsing our website without changing the browser settings you grant us permission to store that information on your device.
The organic compounds which contain the group isothiocyanate (N=C=S) are called isothiocyanates. Allyl isothiocyanate is one of the examples of natural isothiocyanates which is also known as mustard oil. The plant species of the order Brassicales, such as wasabi, horseradish, and radish, produce glucosinolates, which is converted by the enzyme myrosinase into isothiocyanate and have specific flavours because of the presence of isothiocyanates. Phenyl isothiocyanate is used for amino acid sequencing in the Edman degradation. Methyl isothiocyanate is a precursor to a wide variety of important biologically active compounds, and hence it is one of the most important organic isothiocyanate in the chemical industry.
Isothiocyanates are of interest in food science and medicine because of their natural abundance in plants coupled with diverse biological effects. These compounds are considered as a class of phytochemicals which have significant scope in preventing cancer. They are found to exhibit anti-tumor activity through several pathways including apoptosis, oxidative stress, MAPK signaling, and oxidative stress. (Review: Are isothiocyanates potential anti-cancer drugs? Wu, X. et al., Acta Pharmacologica Sinica, 2009, 30, 501512). Fluorescein isothiocyanates (FITC) are used as a short-term cell lineage marker in the peri-implantation mouse embryo in order to observe an unusual permeability of embryonic plasma membranes. The other interesting applications of isothiocyanates include: labeling reagents for proteins and other biomolecules, food additives, and preservatives.