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Maybridge Pre-plated Screening Compounds and Fragment Libraries

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Maybridge screening collections and fragment libraries accelerate the drug discovery process

For over 50 years, Maybridge, a part of ThermoFisher Scientific, has been at the forefront of innovative screening compound design, fueled by the desire to access novel molecules of pharmaceutical interest and understand the needs of the drug discovery scientist.

The Maybridge Screening Collection is a highly diverse set of over 53,000 hit-like and lead-like molecules widely acknowledged as a critical tool in screening campaigns. Selected compounds from the collection are available in three pre-plated formats:

 

In addition, the Maybridge Fragment Collection of 30,000 chemical fragments that accelerate structure-based lead identification features the Maybridge PAINS Free Fragment Library, the industry-leading library for fragment-based drug screening.
 

To place an order or further discuss what Maybridge has to offer:   Contact us 

 

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Maybridge HitDiscover: the entire Maybridge Screening Collection pre-plated
A ready to screen collection of 52,160 Maybridge Screening compounds in dry film format, the compounds are of minimum 90% purity and pre-plated as 1umol dry films in 96 well plate format, offering exceptional diversity and outstanding value. Immediate re-supply is available on the majority of the compounds.

Compounds are currently not searchable directly in this website. Download the Maybridge HitDiscover Collection zip file from maybridge.com as Excel with SMILES and SD file format. 

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Maybridge HitFinder: representing the diversity of the entire Maybridge Screening Collection
HitFinder Compounds are selected from the Maybridge Screening Collection using a clustering algorithm employing standard Daylight fingerprints with the Tanimoto similarity index (J.Chem.Inf.Comput.Sci.,1999, 39, 747-750), clustering at 0.7 similarity. All compounds fit Lipinski guidelines for “Drug-likeness” (cLogP ≤5, H-bond acceptors ≤10, H-bond donors ≤5, Molecular Weight ≤500), and all have purity greater than 90%. Each plate represents a unique sample from this selection, is diverse in its own right, and available pre-plated at 1μmol in 96-well plates or .25μmol in 384-well microplates.

Maybridge mini HitFinder includes 2000 diverse compounds randomly selected from the Maybridge HitFinder. Good for start-up Discovery programs where funding is limited, it is offered off-the-shelf preplated at 1µmol dry film in 96-well plates . Stock is available for follow up work when required

Compounds are currently not searchable directly in this website.  Download the Maybridge HitFinder Collection zip file from maybridge.com as Excel with Smiles and SD file format. 

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Maybridge HitCreator: The ultimate diversity screening library
This new offering takes away the need to choose between different libraries by providing the ultimate coverage of drug-like chemical space with a single library. Building on over 50 years of expertise in designing industry leading screening libraries the pre-plated HitCreator represents the diversity of a 550,000 compound library distilled to 14,000 molecules. Each HitCreator is conveniently supplied as dry films in 1μmol in 96 shallow-well plates or .25μmol in 384-well microplates.

Compounds are currently not searchable directly in this website.  Download the Maybridge HitCreator Collection from maybridge.com zip file as Excel with Smiles and SD file format. 


Maybridge Fragment Collection
In addition to the above world-leading pre-selected libraries, Maybridge offers 30,000 chemical fragments that accelerate structure-based lead identification, from which customers can select any combination of fragments to suit their own program. Fragment screening has become a method of choice in the quest for rapid identification of new lead molecules in drug discovery due to the higher hit probability and fewer fragments needing to be screened. The Maybridge fragment library is a proven, industry-leading library due to its diversity, pharmacophoric content and novelty.

Maybridge PAINS Free Fragment Library: the industry-leading library for fragment-based drug screening
The Maybridge Ro3 Library is a diverse selection of 2500 products from the complete Fragment Collection. It is fully Ro3 compliant with assured quality of >= 95% purity and assured solubility. A premium set of 2000 have Aqueous NMR available.This specialty library has been filtered to remove pan assay interference compounds (PAINS), avoiding false hits. 

Other specialty fragment libraries include:

  • Maybridge Bromo-Fragment Collection: More than 1,500 bromine containing fragments for X-ray based fragment screening
  • Maybridge Fluoro-Fragment Collection: More than 5,300 fluorine containing fragments ideal for 19F NMR based fragment screening
  • Maybridge Pre-Fragment Collection: A valuable source of reactive “pre-fragments” for synthesising your own fragments or evolving your hits
     


To place and order or further discuss what Maybridge has to offer:   Contact us 

 
     

 

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