I agree Our site saves small pieces of text information (cookies) on your device in order to deliver better content and for statistical purposes. You can disable the usage of cookies by changing the settings of your browser. By browsing our website without changing the browser settings you grant us permission to store that information on your device.
Morpholines [4-aza-1-oxacyclohexanes] are six-membered saturated organic heterocycles, containing nitrogen and oxygen at the 1- and 4- positions in the ring. Morpholine is a mild base; its conjugate acid is called morpholinium. The presence of ether oxygen renders morpholines less basic than the analogous piperidines.
Morpholine acts as a solvent for a number of organic compounds, such as resins, dyes, and waxes. Morpholine-based enamines are widely used in organic synthesis for C-C and C-X bond formations. Morpholine fatty acid salts are used as surface-active agents and emulsifiers. Morpholines are used in the preparation of several pharmaceuticals, including antibiotics, anticancer agents, and analgesics. Morpholine compounds are used as corrosion inhibitors, antioxidants, plasticizers, viscosity enhances, local anesthetics, and antiseptics. It has a peculiar property in that it remains highly volatile in aqueous solutions and hence is used as a corrosion inhibitor in boilers.
Thiomorpholines [4-thiapiperidine] are six-membered saturated organic heterocyclic compounds containing nitrogen and sulfur at the 1- and 4- positions of the ring. It can be considered as a thio analog of morpholine. Thiomorpholine derivatives are associated with a variety of pharmacological activities including antimycobacterial, antibacterial, apilepsy, antimalarial, and analgesic activities. Thiomorpholines and morpholines are reported to be tachynin receptor antogonists, useful in the treatment of inflammatory diseases.