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Named Reactions in Organic Synthesis

 

named reactions in organic chemistry

Discover the most important named reactions

Today, named chemical reactions play a crucial role in organic synthesis, which continues to grow in its ability to construct ever more complex and diverse chemical molecules.

The first named reaction in organic synthesis, the Lieben Haloform Reaction, had its origin in 1822 when Serullas found that iodine crystals dissolved in a mixture of alkali and ethanol yielded a yellow precipitate which he called “hydroiodide of carbon”, today we know this as iodoform (CHI3).

In 1870, A. Lieben studied the reaction of many carbonyl compounds with iodine and alkali, and postulated rules that formed the basis for the iodoform test. Before spectroscopic methods became widely available for structural identification, the iodoform test helped identify the structure of many organic molecules.

To this day, many new chemical reactions are being reported and named after their discoverers in recognition of their valuable contribution to synthetic organic chemistry.



New!

Reactions Involving Radicals (Radical Reactions!)

 


Which is your favorite named reaction?   Vote now

 

Visit our reaction categories pages for details on the history, applications, and mechanisms of key named reactions, and don’t forget to vote for your favorite.

  • Electrophilic aromatic substitution reactions
    • Friedel-Crafts akylation and acylation, Fries rearrangement, Gattermann-Gattermann-Koch formylation, and Houben-Hoesch synthesis
  • Nucleophilic substitution reactions
    • Gabriel synthesis, Mitsunobu reaction, Baeyer-Villiger oxidation, Swern oxidation, and Tishchenko reaction
  • Heterocycle formation
    • Fischer indole synthesis, Hantzsch dihydropyridine synthesis, Knorr pyrrole synthesis, Pictet-Spengler tetrahydroisoquinoline synthesis, Pomeranz-Fritsch reaction
  • Oxidation
    • Dess-Martin oxidation, Jones oxidation, Oppenauer oxidation, Rubottom oxidation, Sharpless asymmetric epoxidation
  • Reduction reactions
    • Clemmensen reduction, Luche reduction, Meerwein-Ponndorf-Verley reduction, Staudinger reaction, Wolff-Kishner reduction
  • Rearrangement reactions
    • Beckmann rearrangement, Curtius rearrangement, Claisen rearrangement, Ferrier reaction, Hofmann rearrangement
  • Electrophilic addition reactions
    • Noyori asymmetric hydrogenation, Prilezhaev reaction, Schwartz hydrozirconation, Shi asymmetric epoxidation, Simmons-Smith cyclopropanation

 

Which is your favorite named reaction?   Vote now

 

Upcoming organic synthesis reaction categories:

Pericyclic reactions
Photochemical reactions

Other reaction categories include: Carbocycle formation, Cyclo-aromatization, Degradation, Elimination reactions, Fragmentation reactions,  and reactions involving Carbenes.

 

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