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In an amine, one or more of the hydrogen atoms from ammonia are replaced by organic substituents like alkyl and aryl groups. Most common alkyl amines are liquids, and high molecular weight amines are solids at room temperature. Liquid amines have a distinctive "fishy" smell. Like ammonia, amines are reasonably strong bases. Basicity of the amines is based on the availability of the lone pair of electrons and electronic properties of the substituents.Amines are good ligands for metal ions in giving coordination complexes; aromatic amines react with nitrous acid to give diazonium salts which are used to prepare dyes. For example, aniline is an important precursor in the manufacturing of man-made dyes. Amines are substrates for the preparation of other important organic compounds such as imines, amides, quaternary, and ammonium salts. Amines have a wide range of applications both in the chemical and biological fields. Amines play an important role as neurotransmitters (epinephrine, norepinephrine, dopamine, serotonin, and histamine), subsequently, many drugs are designed to interfere with the action of natural amine neurotransmitters. Industrially amines are used in natural gas and refinery process streams. They also are used in polymer industry as monomers. Amines find use as additives for lubricating oils, engine fuels, and asphalt, and are producers of ethanolamines.