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Organic fluoro compounds refer to those organic compounds that have a Carbon-Fluorine bond. They are also alternatively referred to as organofluoro or organofluorine compounds. Fluorine has several distinctive features such as a strong and short C-F bond, a high dipole moment of the C-F bond due to the high electronegativity of fluorine, and a van der Waal radius that is comparable to hydrogen due to the above; the physical and chemical properties of organofluorines are also distinctive in comparison to other organohalogens. Organofluorine compounds are useful laboratory reagents, such as Triflic acid (trifluoromethanesulfonic acid) and trifluoroacetic acid, used frequently in organic synthesis. The triflate group is a good leaving group and is employed in several substitution and coupling reactions.
In the field of pharmaceuticals, organofluorine compounds are frequently encountered largely due to the fact that fluorine acts as a bioisostere of hydrogen. For the same reason, they are also used as agrochemicals. As pharmaceuticals, they find applications in antibiotics, as sedatives, and for cancer treatment; subsequently several of the top pharmaceutical drugs contain fluorine. Ethers substituted with fluorine are employed as volatile anesthetics. In metered-dose inhalers, which are used to administer some asthma medications, flurorocarbons find application as propellants. Surfactants derived from fluoro-compounds are known to significantly lower surface tension. Hydrofluorocarbons are used as refrigerants. In materials science, organofluorine compounds have been employed in many niche applications. Fluid fluoropolymers, having a low coefficient of friction, find use as specialty lubricants.