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Organophosphorus acids are organic compounds containing oxoacids of phosphorus and at least one phosphorus-carbon bond. Alkyl and aryl phosphonic, phosphonous, phosphinous, and phosphinic acids are typical examples of this class. Generally two types of organophosphorus acids have been reported, one is saturated and the other one is unsaturated organophosphorus acids.
Specifically, alkene substituted phosphonous acids are commonly used as ingredients in detergents, wetting agents, and foam agents. Additionally, these acids can be converted to a number of derivatives suitable for the manufacture of oil additives, plasticizers, and various other useful compositions. In addition, there are several organophosphorous acids that have been developed in the pharmaceutical area owing to their desirable biological activities. For example, there are a number of bisphosphonic acid derivatives used in the prevention and treatment of osteoporosis.
Organophosphorus amides are organic compounds containing at least one phosphorous-nitrogen bond. They can be also referred to as amides of organophosphorous acids. These compounds are physically more stable in open air and soluble in many organic solvents. Organophosphorus amides have also attracted the development of new molecules with wide ranging applications. HMPT (hexamethylphosphorous triamide) is useful as a phosphorylating agent in synthetic chemistry and as a flame retardant in building materials. Hexamethylphosphoramide (HPMA) is useful as a specialty solvent and improves selectivity and the rate of reaction.