I agree Our site saves small pieces of text information (cookies) on your device in order to deliver better content and for statistical purposes. You can disable the usage of cookies by changing the settings of your browser. By browsing our website without changing the browser settings you grant us permission to store that information on your device.
Piperazines (also known as 1,4-hexahydropyrazines) are saturated analogs of pyrazines. The piperazine ring plays a vital role in biological research and the drug manufacturing industry. A large number of commonly used drugs contain a piperazine moiety, like antianginals, antidepressants, antihistamines, antipsychotics, recreational drugs, urologicals, antihistaminic, anthelmintic, antibacterial, antiallergenic, antiemetic, and antimigraine agents. In general, they can be grouped as phenylpiperazines, benzylpiperazines, benzhydrylpiperazines, pyridinylpiperazines, pyrimidinyl-piperazines, or tricyclics. In addition, piperazine hydrate and piperazine citrate are used as a poultry deworming and a roundworm treatment drug in dogs and cats. Substituted piperazine derivatives occupy an important position both as bioactive targets and useful synthetic intermediates. Piperazine derivatives have also been used in various industries as raw materials for the production of hardeners of epoxy resins, corrosion inhibitors, accelerators for rubber, urethane catalysts, and antioxidants.
Homopiperazines (also known as 1,4-Diazacycloheptane, 2,3,4,5,6,7-Hexahydro-1H-1,4-diazepine) are seven-membered heterocyclic organic compounds with two nitrogen atoms in the 1- and 4-positions. Homopiperazine based compounds have been used as building blocks for several drug molecules owing to their potent biological activities. One of these compounds is 1-methylhomopiperazine, which is used as an intermediate for the preparation of several biologically active compounds. Homopiperazine-based compounds have also been used as corrosion inhibitors.