I agree Our site saves small pieces of text information (cookies) on your device in order to deliver better content and for statistical purposes. You can disable the usage of cookies by changing the settings of your browser. By browsing our website without changing the browser settings you grant us permission to store that information on your device.
Piperidines [Hexamethyleneimine; azcyclohexane; Hexahydropyridine] are six-membered saturated heterocyclic organic compounds with one nitrogen atom. Piperidine adopts two chair conformations, which rapidly interconvert through nitrogen inversion. It can be naturally obtained from black pepper, and so the name comes from Piper, the latin word for pepper.
Piperidine can be used as a solvent and a base. Piperidine is a widely used secondary amine. It is widely used to convert ketones to enamines, which can be used in the Stork enamine alkylation reaction. It is used both as a reagent and building block in several synthetic applications. A salt of piperidine with acetic acid is an excellent catalyst for many condensation reactions.
The piperidine skeleton is present in several natural alkaloids, for example, coniine, piperine, anabasine, solenopsin, lobeline, etc. In addition to other applications, it can be used in chemical degradation reactions, such as the sequencing of DNA in the cleavage of particular modified nucleotides. Piperidine is widely used as an excellent base for quantitative deprotection of Fmoc group from peptides in solid-phase peptide synthesis.