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Piperidone (also known as piperidinone or azinanone) is a saturated heterocyclic organic compound containing one nitrogen atom, and a carbonyl group in the ring. It exists in different isomeric forms, such as 2-piperidone, 3-piperidone and 4-piperidone. The Petrenko-Kritschenko piperidone synthesis is one of the main named reactions for the preparation of piperidone derivatives, which involves the reaction of alkyl-1,3-acetonedicarboxylate with benzaldehyde and an amine.

Piperidone-based compounds have received much attention for drug discovery research. Owing to the presence of a carbonyl group and a secondary amine group, both containing alpha-protons, the piperidone structure is a versatile moiety and finds wide applications in synthetic organic chemistry and medicinal chemistry. Piperidone-derived imines and enamines play an important role in several synthetic transformations (Kuznetzov, K. V., “gamma-Piperidone imines and enamines in organic synthesis”, Chemistry of Heterocyclic Compounds 1993, 30(1), 1-13). Besides the interesting structural features, these compounds are also of pharmaceutical interest as they exhibit a wide range of biological activities. Specifically, 2-piperidones have been used both as target molecules and as intermediates in the synthesis of several piperidine derivatives. 4-Piperidone is used as an intermediate in the manufacture of chemicals and pharmaceutical drugs. Hydroxylated piperidine alkaloids also have shown a wide range of biological activities due to their ability to imitate carbohydrates in a variety of enzymatic processes.

  • 1-(2-Phenylethyl)-4-piperidone, 98%
  • 1,3-Dimethyl-4-piperidone, 95%
  • 1-Acetyl-4-piperidone, 99%
  • 1-Benzoyl-4-piperidone, 98+%
  • 1-Benzyl-3-ethoxycarbonyl-4-piperidone hydrochloride hydrate, 97%, ca 10% water
  • 1-Benzyl-3-piperidone hydrochloride hydrate
  • 1-Benzyl-4-piperidone, 98+%
  • 1-Benzyloxycarbonyl-4-piperidone, 98+%
  • 1-Boc-2-piperidone, 99%
  • 1-Boc-2-trifluoromethyl-4-piperidone, 95%
  • 1-Boc-3-fluoro-4-piperidone, 95%
  • 1-Boc-3-piperidone, 97%
  • 1-Boc-4-piperidone, 97+%
  • 1-Cyclopropyl-4-piperidone, 98%
  • 1-Ethoxycarbonyl-4-piperidone, 99%
  • 1-Ethyl-4-piperidone, 98%
  • 1-Fmoc-3-piperidinone, 96%
  • 1-Isopropyl-4-piperidone, 99%
  • 1-Methyl-4-piperidone, 98%
  • 1-n-Propyl-4-piperidone, 98%
  • 2,2,6,6-Tetramethyl-4-piperidone monohydrate, 99%
  • 3-Methyl-1-(2-phenylethyl)-4-piperidone, 97%
  • 4-Piperidone hydrochloride monohydrate, 98%
  • DL-Pipecolinic acid, 99%
  • Ethyl 1-Boc-3-oxopiperidine-4-carboxylate, 97%
  • Ethyl 4-piperidone-3-carboxylate hydrochloride, 97%
  • Ethyl (R)-(+)-1-Boc-4-oxopiperidine-2-carboxylate, 95%
  • (R)-(+)-1-Boc-4-oxopiperidine-2-carboxylic acid, 95%
  • (S)-(-)-1-Boc-4-oxopiperidine-2-carboxylic acid, 95%


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