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Antagonists block the action of agonists which means antagonists are receptor ligands that block or dampen agonist responses upon binding. Antagonists do not provoke any biological effects on their own but prevent actions from agonists. Antagonists can bind receptors at the same or different sites as an agonist would, and their effect can be reversible or irreversible. Antagonists bring conformational changes to the receptor when bound and helps the cells to maintain the neutral signal transduction activity irrespective of whether agonists are bound or not. In other words, antagonists do not need agonists for their activity to neutralize the signal transduction. Alfa Aesar offers a wide range of molecules that act as antagonists in different cell signaling pathways.