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Calcium (Ca), sodium (Na) and potassium (K) channels are pore-forming proteins that regulate the flow of these ions across cell membranes. They play key roles in many biological processes, but are especially important in neurotransmission. They are also involved in many biological activities that involve rapid changes in cells such as muscle contraction and T-cell activation. Channel blockers are drug molecules that bind to these protein pores of specific channels and block the ion flow through these channels. This results in the alteration in the electrochemical gradient of the cell membrane. Alfa Aesar provides a range of channel blocking compounds which include Ca, Na and K channel blockers to aid cell signaling research.