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Inhibitors bind to enzymes and decrease or prevent their biological activity. They may bind in an enzymeÆs active site or at some other site on the protein. The inhibitorÆs activity can be reversible or irreversible. Reversible inhibitors bind non ûcovalently to an enzyme or enzyme-substrate complex. Irreversible inhibitors typically form covalent linkages to an enzyme, changing it chemically so it can no longer catalyze a reaction. Signal transduction pathways are altered in disease systems and are the target for novel drug therapy. Alfa Aesar supplies a wide range of products that act as inhibitors for various signal transduction pathways. These products can be used for therapeutic strategies by inhibiting signaling pathways of interest.