I agree Our site saves small pieces of text information (cookies) on your device in order to deliver better content and for statistical purposes. You can disable the usage of cookies by changing the settings of your browser. By browsing our website without changing the browser settings you grant us permission to store that information on your device.
Spiro compounds are bi- or polycyclic organic compounds with the rings connected through one common atom. The atom connecting the rings is called a spiro atom. Carbon is the most common spiro atom; however spiro compounds are known to contain nitrogen, phosphorus and boron or metals such as copper, zinc or beryllium. They generally exhibit axial chirality.
Spiro compounds such as spiroketals are present widely in natural products. They are used as plasticizers, in perfumes, intermediate products in the synthesis of epoxy and in producing medicine. Spiro forms of lactones and oxazines find applications as leuco dyes, by frequently displaying chromism - reversibly interchanging between their colorless and colored forms. Spiro compounds are used as photochromic materials. They behave as mimetics and as enzyme inhibitors. More and more bioactive compounds containing spiro rings are being explored in drug discovery. This is in part due to the presence of unique, and greater three dimensionality of spiro compounds. Spiro containing molecules such as irbesartan, trospium, spiraprilat, buspirone and cevimeline, have been investigated as pharmaceuticals.