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Sulfonamides belong to the class of compounds that contain the functional group -S(=O)2-N. The S-N bond in a sulfonamide compound is relatively difficult to cleave making them unreactive. Owing to the rigid nature of the functional group, sulfonamides are generally crystalline. Sulfonamides are important compounds in organic chemistry that have been extensively explored due to their wide-ranging chemical applications. Phenyl triflimide is used as a triflating reagent. The related metal triflimidates find use as catalysts. Chiral sulfonamides have long been used for several asymmetric transformations. Sulfonamides are important intermediates in a number of organic transformations. Sulfonamides are efficient partners in the synthesis of secondary amines and isothiourea.
Industrially, sulfonamides are used as flow-promoting agents for paints and adhesives and as plasticizers for polymers like polyamide because they increase flexibility. Toluenesulfonamides are used as antistatic agents and gloss enhancers in plastic film preparations. In the field of pharmaceutical chemistry, sulfonamide-based drugs are used as antibiotics. anticonvulsants, and diuretics.