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Chromane, also known as benzodihydropyran, is a heterocyclic chemical compound with the structural feature of more complex compounds like vitamins E (tocopherols and tocotrienols) and pharmaceutical drugs like troglitazone, ormeloxifene, and nebivolol. Functionalised chromanes express potentially useful biological activities. An example of a naturally occurring chromane is vitamin E, which acts as an antioxidant. Several chromanes with similar structural moiety exhibit multidrug transporter inhibition, peptidoleukotriene antagonist and biosynthesis inhibition activities. Another example of a biologically active chromane is sorbinil, which functions as an aldose reductase inhibitor.
Chromenes, also known as benzopyrans, are heterocyclic organic compounds that result from the fusion of a benzene ring with a pyran ring. There are two isomers that vary by the orientation of the fusion of the two rings with reference to the oxygen, resulting in chromene (1-benzopyran) and isochromene (2-benzopyran), the number denotes where the oxygen atom is located by standard naphthalene-like nomenclature. The derivatives of benzopyran are potassium channel openers having antihypertensive, cardio-protective, myocardial protective, peripheral vasodilating and anti-ischemic activities.
Flavones are a class of flavonoids having the base structure containing 2-phenylchromen-4-one. Flavones are mainly found in cereals and herbs. Flavones have effects on CYP (P450) activity which are enzymes that metabolize most drugs in the body.